Immunosuppressive monoclonal antibody to CD64 from patients with long-term stable multiple sclerosis
| Autor: | G. Gori Savellini, G. Di Genova, Pasquale Annunziata, Chiara Cioni, Loredana Cantalupo, G. Cusi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
T-Lymphocytes Autoimmunity Epitope Cohort Studies Immunology and Allergy CD64 B-Lymphocytes biology Antibodies Monoclonal Middle Aged Flow Cytometry DNA-Binding Proteins medicine.anatomical_structure Neurology Cytokines Female Antibody Immunosuppressive Agents Adult medicine.drug_class T cell Immunology Enzyme-Linked Immunosorbent Assay Transfection Monoclonal antibody Statistics Nonparametric Cell Line Multiple sclerosis medicine Humans Immunoprecipitation RNA Messenger B cell Cell Proliferation Receptors IgG medicine.disease Myelin basic protein Immunoglobulin M Immunoglobulin G biology.protein Myelin-Oligodendrocyte Glycoprotein Monoclonal antibodies Neurology (clinical) Autoimmunity CD64 Monoclonal antibodies Multiple sclerosis Myelin basic protein Peptides Epitope Mapping Transcription Factors |
| Popis: | High intrathecal levels of anti-myelin basic protein (MBP) IgM were previously found to be significantly associated with early favorable course in a cohort of patients with multiple sclerosis (MS). A mAb to MBP 105–120 recognizing the 222–228 epitope of the extracellular domain of high affinity immunoglobulin gamma Fc-receptor I (CD64) was isolated from EBV + B cell clones of long-term stable RRMS patients. This mAb exerted immunosuppressive activity on MS-derived T cell lines through induction and release of high amounts of interleukin-10 and decreased levels of interleukin-12 from activated monocytes providing the biological basis for a potential new treatment for MS and other immune-mediated neurological disorders. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|