Frosted Branch Angiitis Associated With Cytomegalovirus in a Pediatric Autologous Stem Cell Transplant Patient: Case Report and Review of the Literature
| Autor: | Martha Fulford, Chantel Cacciotti, Dave Lysecki, Marija Kacar, Adam Fleming, Carl Shen |
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| Rok vydání: | 2021 |
| Předmět: |
Vasculitis
Pediatrics medicine.medical_specialty Visual impairment Vision Disorders Congenital cytomegalovirus infection Cytomegalovirus medicine Humans Child Medulloblastoma business.industry Panuveitis Hematopoietic Stem Cell Transplantation Infant Hematology medicine.disease eye diseases surgical procedures operative Oncology Cytomegalovirus Infections Pediatrics Perinatology and Child Health Transplant patient Stem cell medicine.symptom Differential diagnosis business Complication |
| Zdroj: | Journal of Pediatric Hematology/Oncology. 44:e479-e481 |
| ISSN: | 1077-4114 |
| DOI: | 10.1097/mph.0000000000002318 |
| Popis: | Background Frosted branch angiitis (FBA) is a rare phenomenon of panuveitis which may occur secondary to cytomegalovirus (CMV) causing acute visual disturbances. CMV infection is a known complication in allogenic stem cell transplant (SCT) patients but is uncommon following autologous SCT. Observation We describe a 17-month-old medulloblastoma patient with sudden onset visual impairment following second autologous SCT. The patient was CMV seropositive, polymerase chain reaction negative before second SCT. At the time of presentation with visual complaints, the patient was diagnosed with FBA associated with CMV reactivation. Treatment included antivirals and immunosuppressive medication with visual recovery. Conclusion FBA induced by CMV should be considered as a differential diagnosis in pediatric patients undergoing autologous bone marrow transplant with rapidly progressive visual impairment. |
| Databáze: | OpenAIRE |
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