NMDA lesions in the medial prefrontal cortex impair the ability to inhibit responses during reversal of a simple spatial discrimination
| Autor: | Wesley White, Laurent Lacroix, Rodrigo F Salazar, Joram Feldon, Ilsun M. White |
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| Rok vydání: | 2004 |
| Předmět: |
Male
N-Methylaspartate Time Factors Central nervous system Prefrontal Cortex Reversal Learning Gating Open field Discrimination Learning Lesion Behavioral Neuroscience Excitatory Amino Acid Agonists medicine Animals Prefrontal cortex Prepulse inhibition Analysis of Variance Brain Diseases Behavior Animal Neural Inhibition Rats medicine.anatomical_structure Space Perception Facilitation NMDA receptor medicine.symptom Psychology Neuroscience |
| Zdroj: | Behavioural Brain Research. 152:413-424 |
| ISSN: | 0166-4328 |
| Popis: | Although lesion studies suggest that the rat medial prefrontal cortex (mPFc) is involved in the process necessary for reversal of a particular set of contingencies, the nature of lesion-induced deficits is unclear. The involvement of rat mPFc in reversal of a simple spatial discrimination was examined in the present study. Our hypothesis was that lesion-induced deficits may reflect a failure to inhibit a learned instrumental response. Lister Hooded rats were trained on a spatial discrimination task (SD), which required a correct barpress matching the cue location, then they were trained on reversal of SD (SDR), which required a correct barpress opposite to the cue location. Rats with mPFc lesions showed a slower learning rate compared to the controls. However, behavior of the lesioned rats during early and later reversal differed. During the initial SDR, the lesioned rats showed a greater number of barpresses during the intertrial interval and a slightly higher percent correct responses than that of the controls. Our data suggest that damage to mPFc may produce a lack of response inhibition, leading to an increase in nondiscriminated bapresses, thereby yielding a ‘facilitation’ during early reversal. mPFc lesion did not affect either open field activity or prepulse inhibition (PPI), a frequently used measure of sensorimotor gating. Disruption of reversal learning following damage to mPFc is partly due to a failure to inhibit instrumental responses, rather than to disruption of other processes involved in sensorimotor gating or general activity. © 2003 Elsevier B.V. All rights reserved. |
| Databáze: | OpenAIRE |
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