Standardized extract of Erythrina velutina Willd. attenuates schizophrenia-Like behaviours and oxidative parameters in experimental animal models
| Autor: | José Eduardo Ribeiro Honório Júnior, Bianca Oliveira Louchard, Luna Costa Vasconcelos, Antônia Torres Ávila Pimenta, Naiara Coelho Ximenes, Luzia Kalyne Almeida Moreira Leal, Kátia Cilene Ferreira Dias, Jamily Cunha de Almeida, Francisco das Chagas Lima Pinto, Talita Matias Barbosa, Marianna Letícia Vasconcelos Patrocínio, Ana Paula de Azevedo Leitão, Silvânia Maria Mendes Vasconcelos |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Olanzapine Male medicine.medical_treatment Pharmaceutical Science Prefrontal Cortex Striatum Pharmacology medicine.disease_cause Hippocampus Antioxidants 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Medicine Hippocampus (mythology) Animals Ketamine Saline Erythrina biology business.industry Plant Extracts Glutathione biology.organism_classification Corpus Striatum Disease Models Animal Oxidative Stress 030104 developmental biology chemistry Schizophrenia Lipid Peroxidation business 030217 neurology & neurosurgery Erythrina velutina Oxidative stress Locomotion medicine.drug |
| Zdroj: | The Journal of pharmacy and pharmacology. 71(3) |
| ISSN: | 2042-7158 |
| Popis: | Objectives To study the effects of the standardized extract from the leaves of Erythrina velutina in behavioural and oxidative parameters in the ketamine-induced schizophrenia model. Methods Mice received ketamine (KET) or saline for 7 days. From 8th to 14th day, the animals received Erythrine (Eryt) (100, 200 or 400 mg/kg) or olanzapine (Olanz), 1 h after KET administration. At 14th day, 30 min after the last administration of KET, the open-field and pre-pulse inhibition (PPI) tests were performed. Then, the animals were sacrificed and the prefrontal cortex (PFC), hippocampus (HC) and striatum (ST) were dissected for the oxidative tests. Key findings Ketamine increased spontaneous locomotor activity and grooming. KET decreased the PPI, which was reversed by combining it with Eryt or olanzapine. KET decreased GSH concentration in PFC and ST this was reversed by Eryt. KET increased MDA concentration in PFC and HC this was reversed by Eryt. Eryt and Olanzapine reduced MDA concentration in ST when compared to KET group. Nitrite concentration was reduced by administration of KET in the PFC. Conclusions These results demonstrate that the standardized extract of E. velutina can prevent behavioural symptoms and oxidative stress induced by repeated doses of KET. |
| Databáze: | OpenAIRE |
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