Association of bedtime with mortality and major cardiovascular events: an analysis of 112,198 individuals from 21 countries in the PURE study
| Autor: | Ahmad Bahonar, Romaina Iqbal, Salim Yusuf, Jephat Chifamba, Chuangshi Wang, Viswanathan Mohan, Afzalhussein Yusufali, Scott A. Lear, Rajeev Gupta, Rafael Diaz, Wei Li, Prospective Urban Rural Epidemiology (Pure) study investigators, Katarzyna Zatońska, Patricio Lopez-Jaramillo, Shrikant I. Bangdiwala, Iolanthé M. Kruger, Biju Soman, Marc Evans M Abat, Annika Rosengren, Fernando Lanas, Khalid Yusoff, Khalid F. AlHabib, Sumathy Rangarajan, Alvaro Avezum, Bo Hu, Karen Yeates |
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| Přispěvatelé: | Masira |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Health outcomes Bedtime Cardiovascular events 03 medical and health sciences 0302 clinical medicine Risk Factors Epidemiology medicine Humans Prospective Studies Myocardial infarction Risk factor Mortality Association (psychology) Life Style Stroke Proportional Hazards Models business.industry General Medicine medicine.disease 030228 respiratory system Cardiovascular Diseases Heart failure business 030217 neurology & neurosurgery Demography |
| Popis: | Digital Objectives This study aimed to examine the association of bedtime with mortality and major cardiovascular events. Methods Bedtime was recorded based on self-reported habitual time of going to bed in 112,198 participants from 21 countries in the Prospective Urban Rural Epidemiology (PURE) study. Participants were prospectively followed for 9.2 years. We examined the association between bedtime and the composite outcome of all-cause mortality, non-fatal myocardial infarction, stroke and heart failure. Participants with a usual bedtime earlier than 10PM were categorized as ‘earlier’ sleepers and those who reported a bedtime after midnight as ‘later’ sleepers. Cox frailty models were applied with random intercepts to account for the clustering within centers. Results A total of 5633 deaths and 5346 major cardiovascular events were reported. A U-shaped association was observed between bedtime and the composite outcome. Using those going to bed between 10PM and midnight as the reference group, after adjustment for age and sex, both earlier and later sleepers had a higher risk of the composite outcome (HR of 1.29 [1.22, 1.35] and 1.11 [1.03, 1.20], respectively). In the fully adjusted model where demographic factors, lifestyle behaviors (including total sleep duration) and history of diseases were included, results were greatly attenuated, but the estimates indicated modestly higher risks in both earlier (HR of 1.09 [1.03–1.16]) and later sleepers (HR of 1.10 [1.02–1.20]). Conclusion Early (10 PM or earlier) or late (Midnight or later) bedtimes may be an indicator or risk factor of adverse health outcomes. Ciencias Médicas y de la Salud |
| Databáze: | OpenAIRE |
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