Predictive value of interferon-gamma release assays for postpartum active tuberculosis in HIV-1-infected women
| Autor: | Grace John-Stewart, Dalton Wamalwa, Sasi R. Jonnalagadda, Elizabeth R. Brown, Barbara Lohman-Payne, Carey Farquhar |
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| Rok vydání: | 2013 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Time Factors Tuberculosis HIV Infections Kaplan-Meier Estimate Gastroenterology Mycobacterium tuberculosis Interferon-gamma Predictive Value of Tests Pregnancy Internal medicine medicine Humans Receiver operating characteristic biology Coinfection business.industry Incidence Incidence (epidemiology) Postpartum Period medicine.disease biology.organism_classification Kenya CD4 Lymphocyte Count Infectious Diseases ROC Curve Area Under Curve Predictive value of tests Immunology HIV-1 Female business Biomarkers Interferon-gamma Release Tests Postpartum period |
| Zdroj: | The International Journal of Tuberculosis and Lung Disease. 17:1552-1557 |
| ISSN: | 1815-7920 1027-3719 |
| DOI: | 10.5588/ijtld.13.0239 |
| Popis: | BACKGROUND Data on the prognostic utility of interferon-gamma release assays (IGRAs) for active tuberculosis (TB) among human immunodeficiency virus 1 (HIV-1) infected individuals are limited. METHODS Samples from a perinatal cohort of HIV-1-infected women in Kenya, obtained during pregnancy, were tested using T-SPOT®.TB IGRAs to detect Mycobacterium tuberculosis-specific interferon-gamma (IFN-γ) responses. IFN-γ (cut-off values of >0, ≥6 and ≥10 spot-forming cells [SFC]/well) and CD4 cell count (cut-off values of |
| Databáze: | OpenAIRE |
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