Flavonoids products from Nitraria retusa leaves promote lymphoblastoid cells apoptosis
| Autor: | Bouhlel Ines, Kriffi Mounira, Bhouri Wissem, Chekir-Ghedira Leila, Jihed Boubaker, Ghedira Kamel, Ben Sghaier Mohammed, Dijoux Franca Marie Genviève, Skandrani Ines |
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| Přispěvatelé: | Université de Monastir - University of Monastir (UM), Laboratoire d'Ecologie Microbienne - UMR 5557 (LEM), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Ecole Nationale Vétérinaire de Lyon (ENVL)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Ministry of Higher Education, Scientific Research and Technology, Tunisia Ministry of Foreign Affairs, France (Action Integree de Cooperation Inter Universitaire Franco-Tunisienne) CMCU 07 G0836 PAR, Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Ecole Nationale Vétérinaire de Lyon (ENVL) |
| Rok vydání: | 2012 |
| Předmět: |
Cancer Research
Angiosperms Poly ADP ribose polymerase [SDV]Life Sciences [q-bio] Medicine (miscellaneous) Antineoplastic Agents Apoptosis DNA Fragmentation Cell Line 03 medical and health sciences chemistry.chemical_compound Magnoliopsida 0302 clinical medicine Cell Line Tumor Humans Retusa Glycosides Isorhamnetin 030304 developmental biology Flavonoids 0303 health sciences Nutrition and Dietetics Tumor biology Caspase 3 Plant Extracts Lymphoblast biology.organism_classification Plant Leaves Oncology Biochemistry chemistry Cell culture 030220 oncology & carcinogenesis Nitraria retusa DNA fragmentation Quercetin Poly(ADP-ribose) Polymerases |
| Zdroj: | Nutrition and Cancer Nutrition and Cancer, Taylor & Francis (Routledge), 2012, 64 (7), pp.1095-1102. ⟨10.1080/01635581.2012.717680⟩ |
| ISSN: | 1532-7914 0163-5581 |
| DOI: | 10.1080/01635581.2012.717680⟩ |
| Popis: | In this report, the ethyl acetate extract and its major constituent, isorhamnetin 3-o-robinobioside (I3-O-Rob), from Nitraria retusa (N. Retusa) leaf extracts were evaluated for their ability to induce apoptosis in human lymphoblastoid cells (TK6). Apoptosis of TK6 cell line was carried out using DNA fragmentation, poly ADP-ribose polymerase (PARP) cleavage with reference to caspase-3 activity. These tested products, from N. Retusa, enhanced the apoptosis effects in the tested cancer cell line. This result was confirmed by DNA fragmentation and PARP cleavage indicating a release of caspase-3 level. Our results indicate that the original ethyl acetate extract and the I3-O-Rob have a great antiproliferative effect on human lymphoblastoid cells (TK6), which may be due to their involvement in the apoptotic pathway. |
| Databáze: | OpenAIRE |
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