Redox control of protein degradation
| Autor: | Milica Vucetic, Kari E. Fladmark, Antonio Cuadrado, Irina Milisav, Bilge Debelec, Marta Pajares, Samo Ribarič, Irundika H.K. Dias, Huveyda Basaga, Natalia Jiménez-Moreno |
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| Přispěvatelé: | Kidney Research UK, European Cooperation in Science and Technology, UAM. Departamento de Bioquímica, Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ), Instituto de Investigaciones Biomédicas 'Alberto Sols' (IIBM), Ege Üniversitesi |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
GSH
reduced glutathione Clinical Biochemistry NOX nicotinamide adenine dinucleotide phosphate oxidase Review Article Aβ amyloid beta ASK1 apoptosis signal-regulating kinase 1 Protein oxidation Biochemistry HIF-1 hypoxia inducible factor-1 ATG4 autophagy related protein 4 Prion Diseases Unfolded protein response 0302 clinical medicine UPR unfolded protein response Ubiquitin IKKB inhibitor of nuclear factor kappa-B kinase subunit beta Trx thioredoxin Ub ubiquitin 0303 health sciences biology GSSG oxidized glutathione PI3K phosphatidylinositol 3-kinase mTORC1 mammalian target of rapamycin complex 1 Parkinson Disease Cell biology CMA chaperone mediated autophagy Oxidation-Reduction Intracellular Proteasome Endopeptidase Complex Proteinoxidation Medicina Nerve Tissue Proteins TSC2 tuberous sclerosis complex 2 Protein degradation PDIs protein disulfide isomerase ER endoplasmic reticulum 03 medical and health sciences UPS ubiquitin proteasome system NRF1/2 nuclear factor (erythroid-derived 2)-like 1/2 Alzheimer Disease LC3 microtubule-associated protein light chain 3 Autophagy Humans 030304 developmental biology α-SYN α-synuclein ROS reactive oxygen species (mtROS mitochondrial ROS) Proteasome Organic Chemistry PARP1 poly [ADP-ribose] polymerase 1 PrP prion protein (PrPc cellular form PrPsc scrapie form) Ubiquitination ATM ataxia-telangiectasia mutated PTEN phosphatase and tensin homolog ULK1 unc-51 like autophagy activating kinase 1 Proteostasis AMPK AMP activated protein kinase NFκB nuclear factor kappa B PDH prolyl-4-hydroxylase Proteolysis biology.protein Reactive Oxygen Species Protein Processing Post-Translational 030217 neurology & neurosurgery BCL-2 B-cell lymphoma 2 JNK1 c-Jun N-terminal kinase |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid Redox Biology Biblos-e Archivo. Repositorio Institucional de la UAM |
| ISSN: | 2213-2317 |
| Popis: | WOS: 000367338700040 PubMed ID: 26381917 Intracellular proteolysis is critical to maintain timely degradation of altered proteins including oxidized proteins. This review attempts to summarize the most relevant findings about oxidant protein modification, as well as the impact of reactive oxygen species on the proteolytic systems that regulate cell response to an oxidant environment: the ubiquitin-proteasome system (UPS), autophagy and the unfolded protein response (UPR). In the presence of an oxidant environment, these systems are critical to ensure proteostasis and cell survival. An example of altered degradation of oxidized proteins in pathology is provided for neurodegenerative diseases. Future work will determine if protein oxidation is a valid target to combat proteinopathics., (C) 2015 The Authors. Published by Elsevier B.V. European Cooperation in Science and Technology (COST Action)European Cooperation in Science and Technology (COST) [BM1203/EU-ROS]; Kidney Research UKKidney Research UK (KRUK) [PDF3/2014] Several authors of this review were supported by the European Cooperation in Science and Technology (COST Action BM1203/EU-ROS). HKID is funded by Kidney Research UK (PDF3/2014). |
| Databáze: | OpenAIRE |
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