Bisamides from Aglaia species: structure analysis and potential to reverse drug resistance with cultured cells
| Autor: | Jindaporn Puripattanavong, Heebyung Chai, Kittisak Likhitwitayawuid, Ekarin Saifah, Geoffrey A. Cordell, John M. Pezzuto |
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| Rok vydání: | 1993 |
| Předmět: |
Magnetic Resonance Spectroscopy
Stereochemistry Cell Survival Drug Resistance Pharmaceutical Science Pharmacognosy Vinblastine Homonuclear molecule KB Cells Analytical Chemistry chemistry.chemical_compound Alkaloids Amide Drug Discovery Tumor Cells Cultured Humans Pharmacology biology Aglaia Aglaia odorata Alkaloid Organic Chemistry Nuclear magnetic resonance spectroscopy biology.organism_classification Antineoplastic Agents Phytogenic Complementary and alternative medicine chemistry Molecular Medicine Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Journal of natural products. 56(4) |
| ISSN: | 0163-3864 |
| Popis: | The structure of pyramidatine [1], a new bisamide alkaloid from leaves of Aglaia pyramidata, was determined through extensive nmr studies, including homonuclear COSY, NOESY, APT, HETCOR, and selective INEPT techniques. Revision of the 13C-nmr assignment of piriferine [2], an alkaloid previously isolated from A. pirifera, was achieved by examination of several 2D nmr spectra (homonuclear COSY, NOESY, and HETCOR) and confirmed by selective INEPT nmr experiments. Evaluation of the cytotoxic potential of the two alkaloids, along with two other bisamides from Aglaia odorata, odorine [3] and 5'-epi-odorine [4], was carried out in eleven human cancer cell lines. None of these bisamides showed significant cytotoxicity. Nevertheless, piriferine [2], odorine [3], and 5'-epi-odorine [4] were found to inhibit the growth of the vinblastine-resistant KB cells by enhancing the anticancer activity of vinblastine. |
| Databáze: | OpenAIRE |
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