Effects of drug-induced pulmonary phospholipidosis on lung mechanics in rats
| Autor: | P. Camus, U. M. Joshi, M. F. Petrini, David L. Lentz, V. G. Lockard, H. M. Mehendale |
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| Rok vydání: | 1989 |
| Předmět: |
Male
Phentermine medicine.medical_specialty Chlorphentermine Supine position Physiology medicine.medical_treatment Pulmonary compliance Functional residual capacity Reference Values Physiology (medical) Internal medicine medicine Animals Lung volumes Lung Lung Compliance Saline Phospholipids Phospholipidosis Chemistry Body Weight Rats Inbred Strains Organ Size respiratory system Rats Respiratory Function Tests respiratory tract diseases Endocrinology Anesthesia Lung Volume Measurements Transpulmonary pressure medicine.drug |
| Zdroj: | Journal of Applied Physiology. 66:2437-2445 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/jappl.1989.66.5.2437 |
| Popis: | Chronic administration of amphiphilic drugs to rats induces pulmonary phospholipidosis (P), a disease characterized by accumulation of phospholipids and large foamy macrophages in alveolar spaces. We investigated whether P induced by chlorphentermine (CPH) causes changes in lung volumes and mechanics in this species. Groups of rats were fed CPH (50 mg.kg-1.day-1) for 1, 2, 3, 5, 9, and 14 wk. After each treatment period, lung volumes and mechanics were studied in the anesthetized, paralyzed, supine rat. Partial pressure-volume (PV) curves were developed at 3 and 6 ml above functional residual capacity (FRC; PV3, PV6), followed by maximal [up to total lung capacity (TLC)] PV curves. FRC was determined by saline displacement. Lungs were then fixed for histopathological examination. A subgroup of animals was allowed a recovery period of 6 wk, after the 9 wk of CPH administration. Pair-fed rats served as controls (CTR) at each time point. Lung weight increased in CPH-treated (CPH-T) rats from 1.5 +/- 0.2 (SD) g at week 1 to 5.8 +/- 1.4 g at week 14, reflecting the development of P. TLC, FRC, transpulmonary pressure at FRC, the shape of maximal PV curves, and static expiratory lung compliance computed from maximal PV data points did not change in CPH-T rats. However, partial PV curves of CPH-T lungs (particularly PV3) were shifted downward and to the right of those of CTR at 2, 3, 5, and 9 wk, indicating increased recoil pressure in phospholipidotic lungs at these time points.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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