Exclusion of Malignancy in Thyroid Nodules with Indeterminate Fine-Needle Aspiration Cytology After Negative 18F-Fluorodeoxyglucose Positron Emission Tomography: Interim Analysis
| Autor: | Frank J. Quayle, Lourdes R. Ylagan, Hameda B. Hussain, Kathryn Trinkaus, Farrokh Dehdashti, Jeffrey F. Moley, Amber L. Traugott, Mark S. Cohen, Rosa M. Davila, Elizabeth A. Fialkowski |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Thyroid nodules
Adult Male medicine.medical_specialty medicine.medical_treatment Biopsy Fine-Needle Standardized uptake value Malignancy Sensitivity and Specificity Article Fluorodeoxyglucose F18 Predictive Value of Tests Biopsy medicine Humans Prospective Studies Thyroid Nodule Aged Ultrasonography medicine.diagnostic_test business.industry Thyroid Thyroidectomy Nodule (medicine) Middle Aged medicine.disease medicine.anatomical_structure Positron emission tomography Positron-Emission Tomography Surgery Female Radiology medicine.symptom Radiopharmaceuticals business Nuclear medicine Tomography X-Ray Computed |
| Popis: | In all, 20% of fine-needle aspiration (FNA) biopsies of thyroid nodules have an indeterminate diagnosis; of these, 80% are found to be benign after thyroidectomy. Some previous reports indicate that positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) imaging may predict malignancy status. We now report results on the first 51 patients in the largest prospective study of FDG-PET in patients with an indeterminate thyroid nodule FNA. Eligible patients had a dominant thyroid nodule that was palpable or ≥1 cm in greatest dimension as seen by ultrasonography, and indeterminate histology of the FNA biopsy specimen. Participants underwent preoperative neck FDG-PET alone or FDG-PET with computed tomography (FDG-PET/CT). Images were evaluated qualitatively and semiquantitatively using the maximum standardized uptake value (SUVmax). Final diagnosis was determined by histopathologic analysis after thyroidectomy. Descriptive statistical analysis was performed. A total of 51 patients underwent preoperative FDG-PET or FDG-PET/CT. Studies without focally increased uptake localized to the lesion were considered negative. For all lesions (10 malignant, 41 benign), the sensitivity, specificity, positive-predictive value (PPV), and negative-predictive value (NPV) were 80%, 61%, 33%, and 93%, respectively. Postoperatively, two malignant and six benign lesions were found to be |
| Databáze: | OpenAIRE |
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