Changes in dynamic insulin and gastrointestinal hormone secretion in obese children
| Autor: | Joachim Woelfle, Christian L. Roth, Kathleen D. Bongiovanni, Bettina Gohlke |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism media_common.quotation_subject medicine.medical_treatment Amylin Gastrointestinal Hormones Endocrinology Insulin resistance Internal medicine medicine Humans Insulin Peptide YY Obesity Child media_common business.industry digestive oral and skin physiology Appetite medicine.disease Ghrelin Islet Amyloid Polypeptide Pediatrics Perinatology and Child Health Female Insulin Resistance business Energy Metabolism Body mass index Hormone |
| Zdroj: | Journal of pediatric endocrinologymetabolism : JPEM. 23(12) |
| ISSN: | 0334-018X |
| Popis: | Background: Disturbed satiety and hunger perception in obese individuals has been reported, however data on the dynamic changes of hormonal mediators are sparse. Objective: To evaluate the secretion pattern of insulin, ghrelin, peptide-YY (PYY), and amylin via 0 to 180 min oral glucose tolerance testing in obese and lean children. Subjects and Methods: A prospective clinical study was conducted on lean (n=9) and obese (n=20) Caucasian children of comparable age, gender, and pubertal stage. Serial blood samples were collected. Results: Compared to baseline, levels of acylated ghrelin showed a significant decrease in lean (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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