Associations between body weight, hippocampal volume or tissue signal intensity in 12 to 18-year olds
| Autor: | Terry L. Jernigan, Zoe Mestre, Kerri N. Boutelle, Christina E. Wierenga, Linda Chang, Amanda Bischoff-Grethe, Dawn M. Eichen, Thomas Ernst |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Medicine (miscellaneous) 030209 endocrinology & metabolism Hippocampal formation Body weight Hippocampus Article 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine medicine Hippocampus (mythology) Humans 030212 general & internal medicine Obesity Child Nutrition and Dietetics medicine.diagnostic_test business.industry Body Weight Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging Hippocampal volume Female Signal intensity business Neurocognitive Signal Transduction |
| Zdroj: | Obesity (Silver Spring) |
| Popis: | Author(s): Mestre, Zoe; Bischoff-Grethe, Amanda; Wierenga, Christina E; Jernigan, Terry; Eichen, Dawn M; Chang, Linda; Ernst, Thomas; Boutelle, Kerri N | Abstract: ObjectiveThe hippocampus is a key structure in feeding behaviors and weight regulation. Obesity may lead to disruptions in hippocampal structure. In animals, obesity-related factors (e.g., high-fat/sugar foods) are associated with hippocampal insult (e.g., alterations in the blood brain barrier). In humans, individuals with obesity, relative to healthy weight, have smaller hippocampal volumes. Few studies have examined the association between body weight and the hippocampus during adolescence, a critical brain development period. This study examined hippocampal volume and tissue signal intensity in adolescents across the weight spectrum.MethodsStructural magnetic resonance imaging and anthropomorphic data were available for 102 12- to 18-year-old adolescents (53% female; 15.07 [SDn1.84] years; standardized BMI [BMIz] scores using the Centers for Disease Control and Prevention growth charts: 0.54 [SDn1.17]) from the Pediatric Imaging, Neurocognition, and Genetics database. Linear regression models controlling for age, sex, genetic ancestry, scanner, and household income examined the relationship between BMIz, hippocampal volume, and T2-weighted hippocampal signal intensity.ResultsBMIz was negatively associated with T2-weighted hippocampal signal intensity in the left (t = -3.05; P = 0.003; r = -0.21) and right (t = -2.50; P = 0.01; r = -0.36) hippocampi. BMIz was not significantly associated with hippocampal volume.ConclusionsBMIz is associated with hippocampal tissue characteristics during adolescence, which could impact later brain development. |
| Databáze: | OpenAIRE |
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