Mitochondria-associated ER membranes in glucose homeostasis and insulin resistance
| Autor: | Marcelo A. Mori, Logan K. Townsend, Henver Simionato Brunetta |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Physiology Endocrinology Diabetes and Metabolism Adipose tissue 030209 endocrinology & metabolism Mitochondrion Carbohydrate metabolism Endoplasmic Reticulum 03 medical and health sciences 0302 clinical medicine Insulin resistance Adenine nucleotide Physiology (medical) Internal medicine Organelle medicine Animals Homeostasis Humans Insulin Glucose homeostasis Obesity Chemistry Endoplasmic reticulum Intracellular Membranes Endoplasmic Reticulum Stress medicine.disease Mitochondria Glucose 030104 developmental biology Endocrinology Liver Calcium Insulin Resistance Signal Transduction |
| Zdroj: | American Journal of Physiology-Endocrinology and Metabolism. 319:E1053-E1060 |
| ISSN: | 1522-1555 0193-1849 |
| Popis: | Obesity and insulin resistance (IR) are associated with endoplasmic reticulum (ER) stress and mitochondrial dysfunction in several tissues. Although for many years mitochondrial and ER function were studied separately, these organelles also connect to produce interdependent functions. Communication occurs at mitochondria-associated ER membranes (MAMs) and regulates lipid and calcium homeostasis, apoptosis, and the exchange of adenine nucleotides, among other things. Recent evidence suggests that MAMs contribute to organelle, cellular, and systemic metabolism. In obesity and IR models, metabolic tissues such as the liver, skeletal muscle, pancreas, and adipose tissue present alterations in MAM structure or function. The purpose of this mini review is to highlight the MAM disruptions that occur in each tissue during obesity and IR and its relationship with glucose homeostasis and IR. We also discuss the current controversy that surrounds MAMs’ role in the development of IR. |
| Databáze: | OpenAIRE |
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