Cytomegalovirus Latent Infection is Associated with an Increased Risk of COVID-19-Related Hospitalization
| Autor: | Cécile, Alanio, Anurag, Verma, Divij, Mathew, Sigrid, Gouma, Guanxiang, Liang, Thomas, Dunn, Derek A, Oldridge, JoEllen, Weaver, Leticia, Kuri-Cervantes, M Betina, Pampena, Michael R, Betts, Ronald G, Collman, Frederic D, Bushman, Nuala J, Meyer, Scott E, Hensley, Daniel, Rader, E John, Wherry, Ashley N, Vanderbeck |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | The Journal of Infectious Diseases. 226:463-473 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Some risk factors for severe coronavirus disease 2019 (COVID-19) have been identified, including age, race, and obesity. However, 20%–50% of severe cases occur in the absence of these factors. Cytomegalovirus (CMV) is a herpesvirus that infects about 50% of all individuals worldwide and is among the most significant nongenetic determinants of immune system. We hypothesized that latent CMV infection might influence the severity of COVID-19. Our analyses demonstrate that CMV seropositivity is associated with more than twice the risk of hospitalization due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Immune profiling of blood and CMV DNA quantitative polymerase chain reaction in a subset of patients for whom respiratory tract samples were available revealed altered T-cell activation profiles in absence of extensive CMV replication in the upper respiratory tract. These data suggest a potential role for CMV-driven immune perturbations in affecting the outcome of SARS-CoV-2 infection and may have implications for the discrepancies in COVID-19 severity between different human populations. |
| Databáze: | OpenAIRE |
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