Quantification of Organophosphorus Insecticide Removed by Gastric Lavage in Acutely Poisoned Patients: An Observational Study

Autor: Michael Eddleston, John Victor Peter, Ramya Iyyadurai, Jude Joseph Fleming, Kundavaram Paul Prabhakar Abhilash, Audrin Lenin, Vignesh Kumar Chandiraseharan, Asisha Janeela Mathansingh, Arun Jose, Samuel George Hansdak, Thenmozhi Mani, Anand Zachariah
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Mathansingh, A J, Jose, A, Fleming, J J, Abhilash, K P P, Chandiraseharan, V K, Lenin, A, Hansdak, S G, Iyyadurai, R, Mani, T, Peter, J V, Eddleston, M & Zachariah, A 2023, ' Quantification of Organophosphorus Insecticide Removed by Gastric Lavage in Acutely Poisoned Patients: An Observational Study ', Indian Journal of Critical Care Medicine, vol. 27, no. 6, pp. 397-402 . https://doi.org/10.5005/jp-journals-10071-24475
DOI: 10.5005/jp-journals-10071-24475
Popis: Background: The effectiveness of gastric lavage in organophosphorus poisoning has not been established. We assessed the ability of gastric lavage to remove organophosphorus insecticides as a preliminary stage in assessing effectiveness.Methods: Organophosphorus poisoning patients presenting within Results: 42 patients underwent gastric lavage. 8 (19.0%) patients were excluded because of lack of analytical standard for ingested compounds. Insecticides were detectable in the lavage samples of 24/34 (70.6%) patients. Lipophilic organophosphorus compounds were detected in 23/24 patients while no hydrophilic organophosphorus compounds could be detected in six patients with reported ingestion of hydrophilic compounds. For chlorpyrifos poisoning (n=10), only 0.65 (S.D 1.2) mg of estimated ingested amount (n=5) of 8,600 (S.D 3,200) mg was recovered by gastric lavage. The mean proportion of compound removed by initial gastric aspirate was 79.4%and subsequent 3 cycles removed 11.5%, 6.6% and 2.7%. Conclusion: Lipophilic organophosphorus insecticides could be quantified in stomach contents of organophosphorus poisoning patients with the first aspiration or lavage being most effective. The amount removed was very low hence, routine use of gastric lavage for organophosphourus poisoning patients arriving within 6 hours is unlikely to be beneficial.
Databáze: OpenAIRE