Flow mediated dilation of the brachial artery: an investigation of methods requiring further standardization
| Autor: | Mary R. Aulet, Daniel F. Leotta, Marla Paun, Fiona N. Sands, Alon Peretz, Joel D. Kaufman, Jeffrey H. Sullivan, Carol A. Trenga, Edward A. Gill |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male lcsh:Diseases of the circulatory (Cardiovascular) system medicine.medical_specialty Time Factors Brachial Artery Blood Pressure 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Forearm Internal medicine medicine.artery Occlusion medicine Humans 030212 general & internal medicine Brachial artery Angiology Ultrasonography business.industry Ultrasound Repeated measures design Reproducibility of Results Blood Pressure Determination Repeatability Vasodilation Blood pressure medicine.anatomical_structure lcsh:RC666-701 Regional Blood Flow Anesthesia Cardiology Arm Female Endothelium Vascular Cardiology and Cardiovascular Medicine business Research Article |
| Zdroj: | BMC Cardiovascular Disorders BMC Cardiovascular Disorders, Vol 7, Iss 1, p 11 (2007) |
| ISSN: | 1471-2261 |
| Popis: | Background In order to establish a consistent method for brachial artery reactivity assessment, we analyzed commonly used approaches to the test and their effects on the magnitude and time-course of flow mediated dilation (FMD), and on test variability and repeatability. As a popular and noninvasive assessment of endothelial function, several different approaches have been employed to measure brachial artery reactivity with B-mode ultrasound. Despite some efforts, there remains a lack of defined normal values and large variability in measurement technique. Methods Twenty-six healthy volunteers underwent repeated brachial artery diameter measurements by B-mode ultrasound. Following baseline diameter recordings we assessed endothelium-dependent flow mediated dilation by inflating a blood pressure cuff either on the upper arm (proximal) or on the forearm (distal). Results Thirty-seven measures were performed using proximal occlusion and 25 with distal occlusion. Following proximal occlusion relative to distal occlusion, FMD was larger (16.2 ± 1.2% vs. 7.3 ± 0.9%, p < 0.0001) and elongated (107.2 s vs. 67.8 s, p = 0.0001). Measurement of the test repeatability showed that differences between the repeated measures were greater on average when the measurements were done using the proximal method as compared to the distal method (2.4%; 95% CI 0.5–4.3; p = 0.013). Conclusion These findings suggest that forearm compression holds statistical advantages over upper arm compression. Added to documented physiological and practical reasons, we propose that future studies should use forearm compression in the assessment of endothelial function. |
| Databáze: | OpenAIRE |
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