Accelerated developmental adipogenesis programs adipose tissue dysfunction and cardiometabolic risk in offspring born to dams with metabolic dysfunction

Autor:	Sebastian Larion, Radha Dutt Singh, Emma J. Walsh, Anna Mikolajczak, Jennifer A Thompson, Carol Huang, Taylor B Scheidl, Nada A Sallam
Rok vydání:	2021
Předmět:	Male medicine.medical_specialty Physiology Offspring Endocrinology Diabetes and Metabolism Adipose tissue 030209 endocrinology & metabolism Hyperlipidemias Fructose Diet High-Fat 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Metabolic Diseases Pregnancy Physiology (medical) Internal medicine Adipocyte medicine Adipocytes Animals Insulin Triglycerides 030304 developmental biology Cell Size Cardiometabolic risk 0303 health sciences Adipogenesis business.industry Stem Cells Cardiometabolic Risk Factors Endocrinology chemistry Adipose Tissue Lipogenesis Lipidomics Receptors Leptin Female business Developmental programming
Zdroj:	American journal of physiology. Endocrinology and metabolism. 321(5)
ISSN:	1522-1555
Popis:	This study determined if a perturbation in in utero adipogenesis leading to later life adipose tissue (AT) dysfunction underlies programming of cardiometabolic risk in offspring born to dams with metabolic dysfunction. Female mice heterozygous for the leptin receptor deficiency (Het
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70432bee6124f4d70394711b754e32be https://pubmed.ncbi.nlm.nih.gov/34459218 Zobrazit plný text záznamu