Glucocorticoid deprivation alters in vivo glucose uptake by muscle and adipose tissues of GTG-obese mice
| Autor: | Gregory J. Cooney, Ian D. Caterson, S C Blair |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Physiology Endocrinology Diabetes and Metabolism Glucose uptake Mice Obese Adipose tissue White adipose tissue Biology Gold thioglucose Mice chemistry.chemical_compound Insulin resistance Physiology (medical) Internal medicine Brown adipose tissue medicine Hyperinsulinemia Animals Insulin Glucocorticoids Aurothioglucose Glycogen Muscles Body Weight Adrenalectomy Organ Size medicine.disease Glucose Endocrinology medicine.anatomical_structure Adipose Tissue Liver chemistry Corticosterone hormones hormone substitutes and hormone antagonists |
| Zdroj: | American Journal of Physiology-Endocrinology and Metabolism. 269:E927-E933 |
| ISSN: | 1522-1555 0193-1849 |
| DOI: | 10.1152/ajpendo.1995.269.5.e927 |
| Popis: | The effect of 1 wk of glucocorticoid deprivation by surgical adrenalectomy (ADX) on tissue 2-deoxy(-)[U-14C]glucose (2-DG) uptake and hepatic glucose production (HGP) was assessed in conscious, catheterized mice 5 wk after the induction of obesity with gold thioglucose (GTG). Despite the prevailing hyperglycemia and hyperinsulinemia, glucose uptake by heart, quadriceps muscle, and interscapular brown adipose tissue (BAT) of GTG-obese mice was unchanged compared with controls, suggesting that the hyperglycemia of GTG-obese mice is able to compensate for the insulin resistance of these tissues. In contrast, epididymal white adipose tissue (WAT) of GTG-obese mice showed increased glucose uptake with hyperglycemia and hyperinsulinemia. ADX decreased the hyperglycemia and lowered the elevated glycogen content of the liver of GTG-obese mice. ADX reduced glucose uptake by heart and WAT of control and GTG-obese mice, consistent with the concomitant decrease in insulinemia. Glucose uptake by muscle of control and GTG-obese mice was not significantly decreased after ADX despite the decrease in insulin, and ADX increased glucose uptake by BAT of GTG-obese mice, suggesting increased sympathetically mediated thermogenesis in this tissue. HGP was increased in GTG-obese mice compared with controls, and ADX significantly reduced HGP in both GTG-obese and control mice. These results suggest that the improved glucose tolerance of ADX GTG-obese mice and ADX control mice is due to a decrease in HGP rather than an increase in peripheral glucose uptake. |
| Databáze: | OpenAIRE |
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