Osteogenic Effect of High-frequency Acceleration on Alveolar Bone
| Autor: | J.M. Salgueiro, Bandar Alyami, Serafim M. Oliveira, Edmund Khoo, Mani Alikhani, Cristina C. Teixeira, Markos Raptis, Adele L. Boskey |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Molar X-ray microtomography Bone density Acceleration Carbonates Vibration Mandibular first molar Rats Sprague-Dawley Random Allocation Calcification Physiologic Imaging Three-Dimensional Bone Density Osteogenesis Oscillometry Physical Stimulation Spectroscopy Fourier Transform Infrared Microscopy Alveolar Process medicine Animals General Dentistry Dental alveolus Reverse Transcriptase Polymerase Chain Reaction Chemistry Alveolar process Research Reports X-Ray Microtomography Anatomy medicine.disease Biomechanical Phenomena Rats medicine.anatomical_structure Microscopy Fluorescence Microscopy Electron Scanning Molar Third Collagen Stress Mechanical Biomedical engineering Calcification |
| Zdroj: | Journal of Dental Research. 91:413-419 |
| ISSN: | 1544-0591 0022-0345 |
| Popis: | Mechanical stimulation contributes to the health of alveolar bone, but no therapy using the osteogenic effects of these stimuli to increase alveolar bone formation has been developed. We propose that the application of high-frequency acceleration to teeth in the absence of significant loading is osteogenic. Sprague-Dawley rats were divided among control, sham, and experimental groups. The experimental group underwent localized accelerations at different frequencies for 5 min/day on the occlusal surface of the maxillary right first molar at a very low magnitude of loading (4 µε). Sham rats received a similar load in the absence of acceleration or frequency. The alveolar bone of the maxilla was evaluated by microcomputed tomography (µCT), histology, fluorescence microscopy, scanning electron microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR imaging), and RT-PCR for osteogenic genes. Results demonstrate that application of high-frequency acceleration significantly increased alveolar bone formation. These effects were not restricted to the area of application, and loading could be replaced by frequency and acceleration. These studies propose a simple mechanical therapy that may play a significant role in alveolar bone formation and maintenance. |
| Databáze: | OpenAIRE |
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