Cutting Edge: CCR9 Promotes CD8+ T Cell Recruitment to the Brain during Congenital Cytomegalovirus Infection
| Autor: | Zachary T. Hilt, Wisler Charles, Katarina E. Cheng, Cybelle Tabilas, Megan Steinhilber, Samantha P. Wesnak, Norah L. Smith, Chris B. Schaffer, Brian D. Rudd |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 209:2281-2286 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.2200578 |
| Popis: | CD8+ T lymphocytes infiltrate the brain during congenital CMV infection and promote viral clearance. However, the mechanisms by which CD8+ T cells are recruited to the brain remain unclear. Using a mouse model of congenital CMV, we found a gut-homing chemokine receptor (CCR9) was preferentially expressed in CD8+ T cells localized in the brain postinfection. In the absence of CCR9 or CCL25 (CCR9’s ligand) expression, CD8+ T cells failed to migrate to key sites of infection in the brain and protect the host from severe forms of disease. Interestingly, we found that expression of CCR9 on CD8+ T cells was also responsible for spatial temporal positioning of T cells in the brain. Collectively, our data demonstrate that the CMV-infected brain uses a similar mechanism for CD8+ T cell homing as the small intestine. |
| Databáze: | OpenAIRE |
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