Purification and characterization of a calf thymus protein active on lipid metabolism
| Autor: | Santangelo F, Paolo Mondola, Anna Belfiore, Mariarosaria Santillo, Maurizio Bifulco, Carlo Caporale |
|---|---|
| Přispěvatelé: | Mondola, Paolo, Santillo, Mariarosaria, Santangelo, Franco, Caporale, C., Belfiore, Anna, Bifulco, M. |
| Rok vydání: | 1989 |
| Předmět: |
Human skin
Thymus Gland Biology Biochemistry Cell Line chemistry.chemical_compound Animals Humans Cholesterol metabolism Amino Acids Rats Inbred BUF Cells Cultured Proteins Fast protein liquid chromatography Lipid metabolism Fibroblasts Rats Amino acid composition chemistry Liver Receptors LDL Low-density lipoprotein Rat liver LDL receptor Chromatography Gel lipids (amino acids peptides and proteins) Biological Assay Cattle Electrophoresis Polyacrylamide Gel Chromatography Liquid |
| Zdroj: | The International journal of biochemistry. 21(9) |
| ISSN: | 0020-711X |
| Popis: | 1. 1. This work concerns the purification of a calf thymus protein that increases the binding of human 125I-labeled low density lipoprotein (LDL) on both human skin fibroblasts and a special line of rat liver cells, BRL 3A. 2. 2. It was found that the thymus gland affects cholesterol metabolism via an activation of the LDL receptor pathway. 3. 3. Moreover, the thymus protein active on the LDL receptor pathway has a different amino acid composition and molecular weight from other well-characterized thymic peptides. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|