Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities
| Autor: | Kole T. Roybal, Wendell A. Lim |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
T-Lymphocytes Recombinant Fusion Proteins Adoptive Immunology Receptors Antigen T-Cell T cells Bioengineering Disease Biology Lymphocyte Activation Immunotherapy Adoptive Cancer Vaccines Article synthetic Notch 03 medical and health sciences Synthetic biology Immune system Neoplasms Allergy and Immunology Receptors Animals Humans Immunology and Allergy engineered immune cells Natural immune system 5.2 Cellular and gene therapies Inflammatory and immune system T-Cell chimeric antigen receptors Emerging Infectious Diseases 030104 developmental biology Antigen Synthetic Biology immunotherapy Development of treatments and therapeutic interventions Genetic Engineering Neuroscience Synthetic immunology Biotechnology |
| Zdroj: | Annual review of immunology, vol 35, iss 1 |
| ISSN: | 1545-3278 0732-0582 |
| DOI: | 10.1146/annurev-immunol-051116-052302 |
| Popis: | The ability of immune cells to survey tissues and sense pathologic insults and deviations makes them a unique platform for interfacing with the body and disease. With the rapid advancement of synthetic biology, we can now engineer and equip immune cells with new sensors and controllable therapeutic response programs to sense and treat diseases that our natural immune system cannot normally handle. Here we review the current state of engineered immune cell therapeutics and their unique capabilities compared to small molecules and biologics. We then discuss how engineered immune cells are being designed to combat cancer, focusing on how new synthetic biology tools are providing potential ways to overcome the major roadblocks for treatment. Finally, we give a long-term vision for the use of synthetic biology to engineer immune cells as a general sensor-response platform to precisely detect disease, to remodel disease microenvironments, and to treat a potentially wide range of challenging diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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