Bioactive polyprenylated acylphloroglucinol derivatives from Hypericum cohaerens
| Autor: | Xia Liu, Li-Xin Yang, Chun-Yan Wu, Xing-Wei Yang, Jun-Zeng Ma, Jing-Jing Zhang, Gang Xu, Huan Wang, Chao-Qun Chen |
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| Rok vydání: | 2013 |
| Předmět: |
Stereochemistry
Molecular Conformation Pharmaceutical Science Tumor cells HL-60 Cells Phloroglucinol Crystallography X-Ray Molecular conformation Analytical Chemistry chemistry.chemical_compound Inhibitory Concentration 50 Drug Discovery Inhibitory concentration 50 Humans IC50 Nuclear Magnetic Resonance Biomolecular Pharmacology biology Molecular Structure Organic Chemistry Absolute configuration biology.organism_classification Antineoplastic Agents Phytogenic Human tumor Hyperforin Complementary and alternative medicine chemistry Molecular Medicine Cholinesterase Inhibitors Drug Screening Assays Antitumor Hypericum Drugs Chinese Herbal |
| Zdroj: | Journal of natural products. 76(9) |
| ISSN: | 1520-6025 |
| Popis: | Nine new polyprenylated acylphloroglucinol derivatives, hypercohins B–J (1–9), and nine known analogues were isolated from the aerial parts of Hypericum cohaerens. The structures of 1–9 were elucidated based on spectroscopic analysis, and the absolute configuration of 1 was confirmed by X-ray crystallographic analysis. The inhibitory activities of these isolates on acetylcholinesterase and five human tumor cell lines were tested, and hypercohins B–D (1–3) exhibited moderate inhibitory activity (IC50 5.8–17.9 μM) against the tested tumor cell lines. |
| Databáze: | OpenAIRE |
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