Evidence for Exposure to HTLV-III in Uganda Before 1973
| Autor: | W. Carl Saxinger, Paul H. Levine, A. G. Dean, Guy de Thé, Gunhild Lange-Wantzin, Jasmine Moghissi, Francine Laurent, Mei Hoh, M. G. Sarngadharan, Robert C. Gallo |
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| Rok vydání: | 1985 |
| Předmět: |
Male
viruses Population Enzyme-Linked Immunosorbent Assay Biology Antibodies Viral Deltaretrovirus Virus Antigen immune system diseases hemic and lymphatic diseases Immunopathology medicine Humans Uganda Child education Antigens Viral Acquired Immunodeficiency Syndrome education.field_of_study Multidisciplinary virus diseases medicine.disease Burkitt Lymphoma Virology Titer Immunology Coinfection biology.protein Female Viral disease Antibody Retroviridae Infections |
| Zdroj: | Science. 227:1036-1038 |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.2983417 |
| Popis: | Fifty of 75 serum samples collected in the West Nile district of Uganda between August 1972 and July 1973 contained antibodies reactive with human T-cell leukemia (lymphotropic) virus type 3 (HTLV-III; mean titer, 601), while 12 of 75 samples were positive in a similar test for HTLV type 1 (HTLV-1) antibodies (mean titer, 236). The samples were screened by enzyme-linked immunosorbent assay and positive results were confirmed by a newly developed unlabeled antibody-peroxidase procedure with enhanced sensitivity for detection of antibody binding to immunoblots of HTLV-III antigen, demonstrating antibodies to proteins with molecular weights of 24,000, 41,000, and 76,000 in nearly all positive samples. Analysis of titration data indicated enhanced titers of antibody against HTLV-III and HTLV-I when coinfection occurred. The high prevalence and relatively low titers [compared to serum from patients with acquired immune deficiency syndrome (AIDS)] of antibodies recognizing HTLV-III proteins in sera from this population at a time that may predate or coincide with the appearance or spread of the AIDS agent (HTLV-III) suggest that the virus detected may have been a predecessor of HTLV-III or is HTLV-III itself but existing in a population acclimated to its presence. It further suggests an African origin of HTLV-III. |
| Databáze: | OpenAIRE |
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