Distribution of high-risk types of human papillomavirus compared to histopathological findings in cervical biopsies in women
| Autor: | Milica Mijović, Leonida Vitković, Snežana Leštarević, G. Trajković, B. Đerković, Ž. Perišić, Sladjana Savic |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Oncology
Pathology medicine.medical_specialty HPV HSIL LSIL Cervicitis Papanicolaou stain lcsh:Medicine cervix uteri Internal medicine medicine Cervix Colposcopy Cervical cancer Ca planocellulare medicine.diagnostic_test business.industry lcsh:R HPV infection Cancer virus diseases Papanicolaou Test medicine.disease female genital diseases and pregnancy complications medicine.anatomical_structure business |
| Zdroj: | Praxis Medica, Vol 44, Iss 4, Pp 39-44 (2015) |
| ISSN: | 0350-8773 |
| Popis: | Introduction: In over of 99% cases of cervical cancer its appearing is preceded by persistent cervical epithelium infection caused by high-risk oncogenic types of human papillomavirus (HPV). The aim of the study was to examine the distribution of high-risk oncogenic HPV types compared to patohistological diagnoses of cervical diseases in women. Materials and methods: The study included 56 women with suspected premalignant and malignant cervical lesions, due to suspected colposcopic and cytological findings (Papanicolaou test). The HPV typing by 'in situ' hybridization method on high-risk HPV types 16, 18, 31 and 33 was performed in all patients from cervical smear as well as cervical biopsy. Histological findings of cervical biopsy was a 'gold standard' in the analysis of materials. Results: Histologically detected premalignant or malignant changes of the cervix were found at 34 (60.7%) of all 56 examined women: 17 of them had LSIL, 13 of them had HSIL, while 4 had squamous cell carcinoma. A positive HPV test had a 47 (84%) of them with a prove of the presence of one or more types of HPV. The most common type of virus was HPV 16 and it was detected in 27 (48.2%) women, followed by HPV 31 that was detected in 26 (46.4%) women, HPV 18 in 18 (32.1%) of women and HPV 33 in 4 (7.1%) women. The infection caused by oncogenic type HPV16 was significantly more frequent in patients with HSIL and cervical cancer (p |
| Databáze: | OpenAIRE |
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