Müller Glial Cell-Provided Cellular Light Guidance through the Vital Guinea-Pig Retina
| Autor: | Josef A. Käs, Detlev Schild, Ines Erdmann, Silke Agte, Antje Wurm, Sabrina Matthias, Stephan Junek, Andreas Reichenbach, Elke Ulbricht |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Light Signal Transduction
genetic structures media_common.quotation_subject Cell Guinea Pigs Biophysics Biology In Vitro Techniques Retinal Cone Photoreceptor Cells Light scattering Retina Guinea pig 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Optics Imaging Three-Dimensional medicine Contrast (vision) Cellular Biophysics and Electrophysiology Animals Scattering Radiation media_common business.industry Retinal Immunohistochemistry eye diseases medicine.anatomical_structure chemistry light scattering retina Müller cell 030221 ophthalmology & optometry Neuroglia sense organs business 030217 neurology & neurosurgery |
| Popis: | In vertebrate eyes, images are projected onto an inverted retina where light passes all retinal layers on its way to the photoreceptor cells. Light scattering within this tissue should impair vision. We show that radial glial (Mu¨ ller) cells in the living retina minimize intraretinal light scatter and conserve the diameter of a beam that hits a single Mu¨ ller cell endfoot. Thus, light arrives at individual photoreceptors with high intensity. This leads to an optimized signal/noise ratio, which increases visual sensitivity and contrast. Moreover, we show that the ratio between Mu¨ ller cells and cones—responsible for acute vision—is roughly 1. This suggests that high spatiotemporal resolution may be achieved by each cone receiving its part of the image via its individual Mu¨ ller cell-light guide. peerReviewed |
| Databáze: | OpenAIRE |
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