Plasma levels and zymographic activities of matrix metalloproteinases 2 and 9 in type II diabetics with peripheral arterial disease
| Autor: | Salvatore Santo Signorelli, Luigi Di Pino, Marcello Petrina, Manuela Indelicato, Giuseppina Nicotra, Massimo Libra, Grazia Malaponte, Valentina Bevelacqua, Gabriella Celotta, Maria Clorinda Mazzarino, Patrick M. Navolanic, Giuseppe Pennisi |
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| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Arterial disease Gelatinase A Enzyme-Linked Immunosorbent Assay Type 2 diabetes 030204 cardiovascular system & hematology Matrix metalloproteinase Type II diabetes Vascular disease 03 medical and health sciences 0302 clinical medicine Internal medicine Diabetes mellitus Medicine Humans 030212 general & internal medicine Aged Peripheral Vascular Diseases MMP-2 business.industry Plasma levels Middle Aged medicine.disease MMP-9 Peripheral Endocrinology Diabetes Mellitus Type 2 Matrix Metalloproteinase 9 Matrix Metalloproteinase 2 Female Cardiology and Cardiovascular Medicine business Biomarkers Diabetic Angiopathies |
| Popis: | Deregulation of matrix metalloproteinases (MMPs) is an important factor contributing to the development of vascular lesions. Plasma levels and zymographic activities of MMP-2 and MMP-9 were investigated in type II diabetics with ( n = 51) or without ( n = 42) peripheral artery disease (PAD) and in normal volunteers ( n = 23). Plasma MMP-2 levels were higher in type II diabetics with ( p < 0.01) or without ( p < 0.05) PAD in comparison with normal volunteers. Similarly, type II diabetics with ( p < 0.0001) or without ( p > 0.05) PAD had higher plasma MMP-9 levels than normal volunteers. Plasma zymographic activities of both MMP-2 and MMP-9 were positively correlated with their plasma levels. Plasma MMP-2 zymographic activity was higher in type II diabetics with PAD than type II diabetics without PAD ( p > 0.05). Plasma MMP-9 zymographic activity was higher in type II diabetics with ( p < 0.0001) or without ( p < 0.0001) PAD in comparision with normal volunteers. Together, these results indicate that increased plasma levels and zymographic activities of MMP-2 and MMP-9 may contribute to PAD in type II diabetics. In particular, plasma MMP-9 may be a useful marker for the development of vascular disease in type II diabetics. |
| Databáze: | OpenAIRE |
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