Suppressor cells and soluble factors from the spleens of UV-irradiated mice
| Autor: | W J Halliday, Alison Brodie |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
0301 basic medicine
Time Factors Ultraviolet Rays Ratón CD8 Antigens Immunology Spleen Biology T-Lymphocytes Regulatory law.invention Mice 03 medical and health sciences 0302 clinical medicine Cell–cell interaction In vivo law Suppressor Factors Immunologic medicine Animals Immunology and Allergy Cells Cultured Immunosuppression Therapy Mice Inbred BALB C Histocompatibility Antigens Class II Leukocyte Adherence Inhibition Test Cell Biology Adhesion Molecular biology In vitro 030104 developmental biology medicine.anatomical_structure Biochemistry CD4 Antigens Suppressor CD8 030215 immunology |
| Zdroj: | Immunology and Cell Biology. 69:199-204 |
| ISSN: | 0818-9641 |
| DOI: | 10.1038/icb.1991.29 |
| Popis: | Several indices of splenic reactivity were measured daily after ultraviolet (UV) irradiation of mice. Spleen weight increased to a maximum after 5 days. Suppressor cell activity, manifested in various assays, peaked slightly earlier. The ability of passively transferred spleen cells to suppress the induction of contact hypersensitivity (CHS) was maximal after 4 days, as was the production of soluble suppressor factors in culture. The factors were detected by suppression of CHS in vivo and leucocyte adherence inhibition (LAI) in vitro. These assays appeared to detect different factors: an I-J- factor active in CHS assays and an I-J+ factor active in LAI assays. The latter factor required CD4-, CD8+ lymphocytes for its production. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text