Synthesis and Receptor Binding Evaluation of Clavizepine Analogues with No Ring D Substituents
| Autor: | Shirley E. Pullan, Domingo Domínguez, M. Carmen de la Fuente, Ilse Biesmans |
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| Rok vydání: | 2006 |
| Předmět: |
Models
Molecular chemistry.chemical_classification Molecular Structure Chemistry Stereochemistry Organic Chemistry Acetal Azepines Ring (chemistry) Chemical synthesis Sulfonamide chemistry.chemical_compound Xanthenes Receptors Serotonin Electrophile Fumariaceae Stereoselectivity Azepine Derivative (chemistry) Protein Binding |
| Zdroj: | The Journal of Organic Chemistry. 71:3963-3966 |
| ISSN: | 1520-6904 0022-3263 |
| DOI: | 10.1021/jo052320c |
| Popis: | Assembly of the azepine ring of xantheno[9,1-cd]azepines by electrophilic cyclization of sulfonamide acetals provides access to clavizepine analogues in the form of 2,12b-dihydro- or 4-hydroxy-2,3,4,12b-tetrahydro-1H-xantheno[9,1-cd]azepines, in the latter case producing the trans derivative stereoselectively. Binding assays for clavizepine and analogues at adrenergic, dopaminergic, and serotonergic receptors are reported. |
| Databáze: | OpenAIRE |
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