The effect of steroid on myeloid leukemic cells: The potential of short-course high-dose methylprednisolone treatment in inducing differentiation, apoptosis and in stimulating myelopoiesis
Autor: | Gönül Hiçsönmez |
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Rok vydání: | 2006 |
Předmět: |
Male
Acute promyelocytic leukemia Cancer Research Myeloid Acute myeloblastic leukemia Anti-Inflammatory Agents CD34 Antigens CD34 Apoptosis Methylprednisolone Mice Leukocytes medicine Animals Humans Child Myelopoiesis business.industry Cell Differentiation Recovery of Function Hematology Hematopoietic Stem Cells medicine.disease Granulocyte colony-stimulating factor Leukemia Myeloid Acute Leukemia Treatment Outcome medicine.anatomical_structure Oncology Child Preschool Immunology Cancer research Female Bone marrow business |
Zdroj: | Leukemia Research. 30:60-68 |
ISSN: | 0145-2126 |
DOI: | 10.1016/j.leukres.2005.05.015 |
Popis: | Several in vitro studies have shown that dexamethasone (Dex) and prednisolone can induce differentiation of some mouse and human myeloid leukemic cells to macrophages and granulocytes. Based on in vitro experiments, we have shown that short-course (3-7 days) high-dose methylprednisolone (HDMP) (20-30 mg/kg/day) treatment can induce differentiation of myeloid leukemic cells in vivo in children with different subtypes of acute myeloblastic leukemia (AML) (AML-M1, -M2, -M3, -M4, -M7). We have also shown that induction of apoptosis of myeloid leukemic cells with or without differentiation is possible by short-course HDMP treatment. In addition, short-course HDMP treatment has been shown to be effective in accelerating leukocyte recovery, possibly stimulating normal CD34-positive hematopoietic progenitor cells. Addition of HDMP to mild cytotoxic chemotherapy (low-dose cytosine arabinoside (LD-Ara-c), weekly mitoxantrone and Ara-c or 6-thioguanine) increased the remission rate (87-89%) and improved the outcome of AML children. We believe that the results of our 17-year clinical experience will provide important benefits to AML patients. |
Databáze: | OpenAIRE |
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