Placebo effect in child and adolescent psychiatric trials
| Autor: | Mara Parellada, Miguel Moreno, Celso Arango, Ana Espliego, Enrique de Portugal, Carmen Moreno |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Adolescent Psychopharmacology Neurogenesis Psychology Adolescent Alternative medicine MEDLINE Psychology Child Placebo Placebos Child and adolescent Efficacy Child Development medicine Child and adolescent psychiatry Humans Pharmacology (medical) Child Psychiatry Biological Psychiatry Depression (differential diagnoses) Pharmacology Psychotropic Drugs business.industry Mental Disorders Adolescent Development Placebo Effect Clinical trial Psychiatry and Mental health Neurology Controlled Clinical Trials as Topic Neurology (clinical) business |
| Zdroj: | European Neuropsychopharmacology. 22:787-799 |
| ISSN: | 0924-977X |
| DOI: | 10.1016/j.euroneuro.2011.09.007 |
| Popis: | Much literature has been written in the field of child psychiatry regarding the placebo as a tool to test drug efficacy in clinical trials, but quite little regarding the placebo effect itself or its clinical use in child psychiatry. In this article, we aim to critically review the literature regarding the placebo effect in children and adolescents with mental disorders, focusing especially on factors influencing the placebo effect and how they may influence the interpretation of clinical trials. The placebo effect seems to be more marked in children than adults, and particularly in children and adolescents with depression, although it is pervasive across ages and is present in non-psychiatric conditions as well. The use of a placebo in clinical trials as a comparator with drugs that have moderate efficacy at most makes it difficult to obtain positive results, and much effort is needed to design very high quality clinical trials that may overcome the limitations of using a placebo. In addition, the placebo effect across ages and clinical conditions must be tested directly (compared with no treatment whenever possible), in order to characterise which placebos work for what and to determine their use in clinical settings. |
| Databáze: | OpenAIRE |
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