Dietary phytochemical approaches to stem cell regulation
| Autor: | Lik Hang Wong, Hubiao Chen, Jun Shi, Chun Wang Yip, Calvin Kai-Fai Lee, Jack Hei Wan, Alice Hei Yi Man, Sydney C.W. Tang, Yi Gang Shi, George Par Heng Leung, Harry Kwun Hung Liu, Kalin Yan Bo Zhang, Shuai Zhang, Queenie Ming Ngai Lau, Chun Hei Cheung, Kargo Kar Ho Lam |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Homeobox protein NANOG Medicine (miscellaneous) Biology Phytochemical Regenerative medicine 03 medical and health sciences 0404 agricultural biotechnology TX341-641 Transcription factor Protein kinase B 030109 nutrition & dietetics Nutrition and Dietetics Stem cell Nutrition. Foods and food supply Wnt signaling pathway 04 agricultural and veterinary sciences 040401 food science Cell biology RUNX2 Differentiation Self-renewal Food Science |
| Zdroj: | Journal of Functional Foods, Vol 66, Iss, Pp 103822-(2020) |
| ISSN: | 1756-4646 |
| Popis: | Controlling self-renewal and lineage differentiation of stem cells (SCs) is critical for SC therapy in regenerative medicine. Multiple signal pathways such as Wnt, TGF-β and BMP are involved in modulating proliferation or specific differentiation of different types of SCs. Dietary phytochemicals, the major source of new drugs, are found to stimulate self-renewal and sub-population differentiation of SCs by activating/inhibiting the signal pathways (MAPK, canonical Wnt/β-catenin, AKT, etc.) and key transcription factors (OCT4, NANOG, Runx2, etc.). Dietary phytochemicals are important for SC therapy owing to the plethora of targets. In this review, we discussed the SC types and their regulatory mechanism. Applications of phenols, flavonoids, sterols and alkaloids chemicals from food or herbs on targeting SCs along with their molecular mechanisms are also discussed. Dietary phytochemicals are promising to enhance endogenous/exogenous SC therapy in various diseases. |
| Databáze: | OpenAIRE |
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