The influence of influenza virus infections on the development of tuberculosis

Autor: Reinout van Crevel, Sangkot Marzuki, Roelof A. de Paus, Bachti Alisjahbana, Tom H. M. Ottenhoff, Esther van de Vosse, Ruud van Beek, Jaap T. van Dissel, Edhyana Sahiratmadja, Guus F. Rimmelzwaan
Přispěvatelé: Virology
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Male
Disease
Antibodies
Viral
0302 clinical medicine
Interferon
Seroepidemiologic Studies
030212 general & internal medicine
0303 health sciences
biology
Coinfection
Antibody titer
Middle Aged
Reactivation
3. Good health
Co-infection
Infectious Diseases
Influenza A virus
Female
Antibody
Poverty-related infectious diseases Infectious diseases and international health [N4i 3]
medicine.drug
Microbiology (medical)
Adult
Tuberculosis
Adolescent
Immunology
Microbiology
Virus
Mycobacterium tuberculosis
Diabetes Complications
03 medical and health sciences
Young Adult
Immune system
SDG 3 - Good Health and Well-being
Influenza
Human
medicine
Humans
Tuberculosis
Pulmonary
030304 developmental biology
Aged
Poverty-related infectious diseases [N4i 3]
biology.organism_classification
medicine.disease
Virology
Influenza
Indonesia
Susceptibility
Case-Control Studies
biology.protein
Zdroj: Tuberculosis; Vol 93
Tuberculosis, 93, 3, pp. 338-42
Tuberculosis, 93(3), 338-342. Churchill Livingstone
Tuberculosis
Tuberculosis, 93, 338-42
ISSN: 1472-9792
Popis: Recently, it was shown that interferon-gamma mediated immune responses, which play a major role in the control of infection with Mycobacterium tuberculosis (Mtb), can be inhibited by type I interferons. Since type I interferons are abundantly induced during viral infections, we hypothesized that infections with influenza viruses might play a role in the development of active TB disease either directly after exposure to Mtb or through reactivation of latent Mtb infection. To explore this hypothesis we investigated in a retrospective study whether newly diagnosed adult tuberculosis patients from Indonesia had had recent influenza infection. Plasma samples from TB patients and controls were assayed for antibodies against two subtypes of at that time relevant, seasonal influenza A viruses. Overall, no correlation was observed with the presence of antibodies and manifest tuberculosis. Still, antibody titers against circulating A/H3N2 influenza virus were slightly enhanced in tuberculosis patients as compared to controls, and highest in cases of advanced tuberculosis. This suggests that tuberculosis patients were recently infected with influenza, before clinical manifestation of the disease. Alternatively, the production of antibodies and susceptibility to tuberculosis may be influenced by a common confounding factor, for example the ability of patients to induce interferon-a. We conclude that in an endemic country like Indonesia, an influenza virus infection is not a major determinant for developing clinically manifest tuberculosis. (C) 2013 Elsevier Ltd. All rights reserved.
Databáze: OpenAIRE
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