Clinical assessment of stabilisation of renal function after nephrectomy
| Autor: | Akash Agrawal, Debansu Sarkar, Dilip Kumar Pal |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment 030232 urology & nephrology Urology Renal function Adaptive change 030230 surgery Kidney Nephrectomy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Humans Medicine Kidney tumour Retrospective Studies Creatinine business.industry General Medicine medicine.disease Kidney Neoplasms medicine.anatomical_structure chemistry business Glomerular Filtration Rate |
| Zdroj: | Urologia Journal. 88:223-226 |
| ISSN: | 1724-6075 0391-5603 |
| DOI: | 10.1177/0391560320987799 |
| Popis: | Introduction and objective: Nephrectomy leads to derangement of renal function and various adaptive changes by the remaining kidney over a period of time. This study is performed to evaluate the amount of derangement of renal function in donor and radical nephrectomy, how much the remaining kidney adapts over a period of time and the time taken for stabilisation of renal function. Method: A total of 60 patients who underwent nephrectomy (Radical/Donor) were followed up for 12 months with serial estimation of renal function and was compared with preoperative renal function. Data was analysed with statistical analysis. Result: Patients who underwent radical nephrectomy had 37% initial decline in renal function which was later stabilised at 19% lower than baseline value. Patient who underwent donor nephrectomy had initially 39% decline in renal function which was later stabilised at 24% lower than normal. Conclusion: Removal of functional renal tissue led to reduction of renal function. This decline is more evident in the initial post-operative period and then begin to stabilise over months. The greater is the amount of normal tissue removed, the greater is the reduction of renal function and more time it will take to stabilise, increasing overall morbidity of the patient. This study suggests that even patients with normal GFRs should be followed up postoperatively to determine their ultimate renal functional outcomes. |
| Databáze: | OpenAIRE |
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