Enantioselective Synthesis of gem-Diaryl Benzofuran-3(2H)-ones via One-Pot Asymmetric Rhodium/Palladium Relay Catalysis
| Autor: | Dong-Xing Zhu, Wen-Wen Chen, Ming-Hua Xu, Zong-Feng Zhang, Bin Xu |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
010405 organic chemistry
Organic Chemistry Enantioselective synthesis chemistry.chemical_element 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences Rhodium law.invention Catalysis chemistry.chemical_compound chemistry Cascade reaction Relay law Intramolecular force Organic chemistry Physical and Theoretical Chemistry Benzofuran Palladium |
| Zdroj: | Organic Letters. 19:2726-2729 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/acs.orglett.7b01070 |
| Popis: | An asymmetric dual-metal relay catalysis strategy that combines Rh/chiral sulfur-olefin-catalyzed enantioselective 1,2-addition with a Pd-catalyzed intramolecular C-O coupling has been developed. The method allows rapid and efficient synthesis of quaternary carbon-containing gem-diaryl benzofuran-3(2H)-ones in good yields in a highly enantioselective manner (up to 99% ee) through a simple one-pot cascade reaction. |
| Databáze: | OpenAIRE |
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