New foot-and-mouth disease vaccine, O JC-R, induce complete protection to pigs against SEA topotype viruses occurred in South Korea, 2014-2015
| Autor: | Min Ja Lee, Su Hwa You, Hye Eun Jo, Su-Mi Kim, Hyundong Jo, Mi Kyeong Ko, Jong-Hyeon Park, Joo Hyung Choi, Sung Ho Shin, Byounghan Kim |
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| Rok vydání: | 2019 |
| Předmět: |
Swine
viruses Viremia Biology Microbiology Virus Immunity type O vaccine Republic of Korea medicine Animals Viral shedding Swine Diseases Korea General Veterinary Foot-and-mouth disease Outbreak Viral Vaccines medicine.disease Virology Vaccination Titer Foot-and-Mouth Disease Virus Foot-and-Mouth Disease Original Article |
| Zdroj: | Journal of Veterinary Science |
| ISSN: | 1976-555X |
| Popis: | Foot-and-mouth disease (FMD) is an acute epidemic that spreads rapidly among cattle and pigs. In 2014, in Korea, despite enforced vaccination, the type O Southeast Asia (SEA) topotype viruses (Mya-98 lineage) infected mainly cattle and pigs simultaneously, thereby causing enormous damage. If a vaccine that is completely protective against this FMD virus is developed and used, it can become a very important preventive measure in Asia, which is where this type of virus mainly circulates. The SEA topotype has been steadily evolving and transforming into new variations since it became epidemic in Asia. Therefore, it became necessary to develop a new vaccine that could provide protection against the FMD virus strain that was responsible for the 2014-2015 outbreak in Korea. This study aimed to develop a vaccine that would provide complete protection against the SEA topotype FMD virus to control sporadic FMD outbreaks, which occur despite the enforcement of vaccination, and to completely prevent virus shedding, thereby preventing the virus from spreading. The vaccine candidate virus developed in this study showed low pathogenicity and can be distinguished from the wild-type FMD virus strain. The developed vaccine was able to protect mice from SEA and Middle East-South Asia topotype virus strains and induced high titers of antibodies against both virus strains in pigs, thereby confirming the sufficiency of its protective function. In particular, the results of the SEA topotype virus challenge test in pigs revealed that perfect immunity was created in the vaccinated pigs, without virus shedding and viremia. |
| Databáze: | OpenAIRE |
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