Transfer of Metronidazole to Gastric Juice: Impact ofHelicobacter pyloriInfection and Omeprazole
| Autor: | Amanda Aureliano Pereira, Maristela Deguer, C.M. da Silva, F. E. Lerner, G. De Nucci, A. dos L. Santos, Fabiana D. Mendes, Alexandra Bento, J. G. P. Ferraz, Silvana A. Calafatti, H. Piovesana, José Pedrazzoli, Alecir Carvalho |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Spirillaceae Cmax Gastroenterology Helicobacter Infections Metronidazole Internal medicine medicine Humans Saliva Chromatography High Pressure Liquid Omeprazole Cross-Over Studies Gastric Juice Helicobacter pylori biology business.industry Stomach biology.organism_classification Crossover study Anti-Bacterial Agents medicine.anatomical_structure Gastric acid business medicine.drug |
| Zdroj: | Scandinavian Journal of Gastroenterology. 35:699-704 |
| ISSN: | 1502-7708 0036-5521 |
| DOI: | 10.1080/003655200750023354 |
| Popis: | The effects of Helicobacter pylori infection associated with inhibition of gastric acid secretion on the distribution of medications used for H. pylori eradication are poorly understood. The aim of this study was to investigate the effects of a 7-day administration of 20 mg omeprazole on the transfer of metronidazole from plasma to the gastric juice of individuals with and without H. pylori infection.Fourteen H. pylori-positive and 14 H. pylori-negative male volunteers were enrolled in a study with an open, randomized, two-period crossover design with a 21-day washout period between phases. Plasma, salivary, and gastric juice concentrations of metronidazole in subjects with and without omeprazole treatment were measured with reversed-phase high-performance liquid chromatography/liquid chromatography.Metronidazole peak concentration (Cmax) was similar in plasma and saliva and was approximately threefold higher in gastric juice in all groups. Omeprazole treatment increased gastric pH and did not affect metronidazole Cmax or the time required for this to be reached (tmax) in plasma, saliva, or gastric juice. However, omeprazole significantly reduced metronidazole transfer from plasma to gastric juice in H. pylori-positive but not H. pylori-negative subjects, as shown by statistical analysis of AUC(0-2 h).Short-term treatment with omeprazole in H. pylori- positive volunteers reduces the amount of metronidazole transferred from plasma to gastric juice. This seems to occur in a pH-independent form. |
| Databáze: | OpenAIRE |
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