Hypoglycemic effect of Carica papaya leaves in streptozotocin-induced diabetic rats
| Autor: | Teresa Ramón-Frías, Deysi Y. Bermúdez-Ocaña, Arturo Rodríguez-Hernández, Juan C. Díaz-Zagoya, Carlos Alfonso Tovilla-Zárate, Hidemi Aguilar-Mariscal, Andrés E. Castell-Rodríguez, Isela Esther Juárez-Rojop, Pedro H. Miranda-Osorio, Jorge L. Ble-Castillo |
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| Jazyk: | angličtina |
| Předmět: |
Blood Glucose
Male Antioxidant medicine.medical_treatment Hypoglycemic action Pharmacology Antioxidants Diabetes Mellitus Experimental chemistry.chemical_compound Diabetes mellitus medicine Animals Humans Hypoglycemic Agents Insulin Rats Wistar geography geography.geographical_feature_category biology medicine.diagnostic_test Traditional medicine Glycogen business.industry Carica papaya Carica Plant Extracts Diabetes lcsh:Other systems of medicine General Medicine lcsh:RZ201-999 medicine.disease biology.organism_classification Islet Streptozotocin Rats Plant Leaves chemistry Complementary and alternative medicine Lipid profile business medicine.drug Research Article |
| Zdroj: | BMC Complementary and Alternative Medicine BMC Complementary and Alternative Medicine, Vol 12, Iss 1, p 236 (2012) |
| ISSN: | 1472-6882 |
| DOI: | 10.1186/1472-6882-12-236 |
| Popis: | Background Traditional plant treatment for diabetes has shown a surging interest in the last few decades. Therefore, the purpose of this study was to assess the hypoglycemic effect of the aqueous extract of C. papaya leaves in diabetic rats. Several studies have reported that some parts of the C. papaya plant exert hypoglycemic effects in both animals and humans. Methods Diabetes was induced in rats by intraperitoneal administration of 60 mg/kg of streptozotocin (STZ). The aqueous extract of C. papaya was administered in three different doses (0.75, 1.5 and 3 g/100 mL) as drinking water to both diabetic and non-diabetic animals during 4 weeks. Results The aqueous extract of Carica papaya (0.75 g and 1.5 g/100 mL) significantly decreased blood glucose levels (pC. papaya could help islet regeneration manifested as preservation of cell size. In the liver of diabetic treated rats, C. papaya prevented hepatocyte disruption, as well as accumulation of glycogen and lipids. Finally, an antioxidant effect of C. papaya extract was also detected in diabetic rats. Conclusions This study showed that the aqueous extract of C. papaya exerted a hypoglycemic and antioxidant effect; it also improved the lipid profile in diabetic rats. In addition, the leaf extract positively affected integrity and function of both liver and pancreas. |
| Databáze: | OpenAIRE |
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