Antral follicle responsiveness to follicle-stimulating hormone administration assessed by the Follicular Output RaTe (FORT) may predict in vitro fertilization-embryo transfer outcome
| Autor: | A.L. Berwanger da Silva, V. Gallot, Renato Fanchin, Michael Grynberg, V. Genro, Nelly Frydman |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty Pregnancy Rate medicine.medical_treatment Fertilization in Vitro Controlled ovarian hyperstimulation Biology Andrology Follicle-stimulating hormone Ovarian Follicle Ovulation Induction Pregnancy Internal medicine Follicular phase medicine Humans Prospective Studies Ovarian follicle In vitro fertilisation Rehabilitation Pregnancy Outcome Obstetrics and Gynecology Embryo Transfer Antral follicle Embryo transfer Logistic Models Treatment Outcome Endocrinology medicine.anatomical_structure Reproductive Medicine Female Ovulation induction Follicle Stimulating Hormone |
| Zdroj: | Human Reproduction. 27:1066-1072 |
| ISSN: | 1460-2350 0268-1161 |
| DOI: | 10.1093/humrep/der479 |
| Popis: | Looking for a qualitative marker of ovarian function, we aimed to verify whether responsiveness of antral follicles to FSH administration, as reflected by the Follicular Output RaTe (FORT), is related to their reproductive competence.We studied 322 IVF-ET candidates aged 25-43 years who underwent controlled ovarian hyperstimulation with similar initial FSH doses. Antral follicle (3-8 mm) count (AFC) and pre-ovulatory follicle (16-22 mm) count (PFC) were performed, respectively, at the achievement of pituitary suppression (before FSH treatment) and on the day of hCG administration. The FORT was calculated by PFC × 100/AFC. FORT groups were set according to tercile values: low (42%; n= 102), average (42-58%; n= 123) and high (58%; n= 97).The average FORT was 50.6% (range, 16.7-100.0%). Clinical pregnancy rates per oocyte retrieval increased progressively from the low to the high FORT groups (33.3, 51.2 and 55.7%, respectively, P0.003) and such a relationship assessed by logistic regression was independent of the confounding covariates, women's ages, AFC and PFC.The observed relationship between IVF-ET outcome and the percentage of antral follicles that effectively respond to FSH administration reaching pre-ovulatory maturation suggests that FORT may be a qualitative reflector of ovarian follicular competence. Further studies with broader inclusion criteria and more personalized protocols are needed to validate these results. |
| Databáze: | OpenAIRE |
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