SEROLOGICAL RESPONSE TO THE HEPATITIS DELTA VIRUS IN HEPATITIS D
| Autor: | S. Macagno, E. Maran, Robert H. Purcell, M. Rizzetto, Aragona M, C Lavarini, Francesco Caredda, O. Crivelli, Patrizia Farci |
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| Rok vydání: | 1987 |
| Předmět: |
Time Factors
media_common.quotation_subject Radioimmunoassay Virus Serology medicine Humans Hepatitis Antibodies Seroconversion Antigens Viral media_common Hepatitis B Surface Antigens biology business.industry Convalescence General Medicine Hepatitis B Prognosis medicine.disease Hepatitis D Virology Immunoglobulin M Immunoglobulin G Acute Disease Chronic Disease Immunology biology.protein Hepatitis Delta Virus Antibody Viral hepatitis business Follow-Up Studies |
| Zdroj: | The Lancet. 329:478-480 |
| ISSN: | 0140-6736 |
| DOI: | 10.1016/s0140-6736(87)92090-3 |
| Popis: | Sera from 74 hepatitis B surface antigen-positive individuals, who presented with acute hepatitis delta virus (HDV) infection which ran a self-limited course in 58 and progressed to chronicity in 16, were tested over time for HDV markers. In self-limited disease the serum pattern varied from early HD-antigenaemia followed by IgM and IgG anti-HD seroconversion, to the appearance of IgM and IgG anti-HD without antigenaemia, or the isolated expression of either the IgM or the IgG antibody. The typical case of IgM anti-HD was transient and appeared with a mean delay of 10-15 days from admission in the different serological subgroups. The IgG antibody usually developed several weeks later during convalescence. In contrast, patients with disease destined to become chronic had a brisk IgM antibody response and IgG anti-HD was detectable with a mean delay of 15 days; generally, the IgM and the IgG antibody persisted over the follow-up time. IgM antibody to HDV is often the only serological test positive in the clinical stage of hepatitis D and repeated testing for this marker is necessary to diagnose acute HDV co-infection. The serological follow-up provides important prognostic information: waning of IgM confirms resolution of HDV infection, persistence predicts chronicity. |
| Databáze: | OpenAIRE |
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