Olaparib for metastatic breast cancer in a patient with a germline PALB2 variant
| Autor: | Athina Kostara, Hakima Harrach, Mattea Reinisch, Mark H Dyson, Rita K. Schmutzler, Ouafaa Chiari, Sherko Kuemmel, Katja Ziegler-Löhr |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer therapy PALB2 Case Report Palbociclib lcsh:RC254-282 Germline Olaparib 03 medical and health sciences chemistry.chemical_compound Breast cancer 0302 clinical medicine medicine Pharmacology (medical) Radiology Nuclear Medicine and imaging skin and connective tissue diseases business.industry medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Metastatic breast cancer 030104 developmental biology Oncology chemistry 030220 oncology & carcinogenesis PARP inhibitor Cancer research Hormonal therapy business |
| Zdroj: | npj Breast Cancer, Vol 6, Iss 1, Pp 1-4 (2020) NPJ Breast Cancer |
| ISSN: | 2374-4677 |
| DOI: | 10.1038/s41523-020-00174-9 |
| Popis: | There is a strong biologic rationale that poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors may benefit a broader range of metastatic breast cancer (MBC) patients than covered by current approvals, which require a germline BRCA1/2 sequence variant affecting function. We report a patient with germline/somatic BRCA1/2 wild-type MBC, who had a dramatic response to the PARP inhibitor olaparib of at least 8 months’ duration. The patient is a 37-year-old woman with recurrent, hormone receptor-positive, HER2-negative MBC that had progressed despite hormonal therapy and palbociclib. Sensitivity to olaparib was likely conferred by a germline sequence variant affecting function in PALB2 (exon 1, c.18G>T, p.(=)). This case documenting activity of olaparib monotherapy in germline/somatic BRCA1/2 wild-type MBC illustrates that the clinical potential of PARP inhibition in MBC extends beyond currently approved indications to additional patients whose tumors have (epi)genetic changes affecting homologous recombination repair. |
| Databáze: | OpenAIRE |
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