BG1 has a major role in MHC-linked resistance to malignant lymphoma in the chicken
| Autor: | Kazuyoshi Hosomichi, Craig S. Blackmore, Patricia S. Wakenell, Ronald M. Goto, Marcia M. Miller, Takashi Shiina, Yujun Wang, Robert L. Taylor, W. Elwood Briles |
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| Rok vydání: | 2009 |
| Předmět: |
Untranslated region
Lymphoma Molecular Sequence Data Antigen presentation Locus (genetics) Protein tyrosine phosphatase Major histocompatibility complex Major Histocompatibility Complex Marek Disease medicine Animals Allele Alleles Poultry Diseases Genetics Multidisciplinary biology Haplotype Biological Sciences medicine.disease Immunity Innate Haplotypes biology.protein Protein Tyrosine Phosphatases Chickens |
| Zdroj: | Proceedings of the National Academy of Sciences. 106:16740-16745 |
| ISSN: | 1091-6490 0027-8424 |
| Popis: | Pathogen selection is postulated to drive MHC allelic diversity at loci for antigen presentation. However, readily apparent MHC infectious disease associations are rare in most species. The strong link between MHC- B haplotype and the occurrence of virally induced tumors in the chicken provides a means for defining the relationship between pathogen selection and MHC polymorphism. Here, we verified a significant difference in resistance to gallid herpesvirus-2 (GaHV-2)-induced lymphomas (Marek's disease) conferred by two closely-related recombinant MHC- B haplotypes. We mapped the crossover breakpoints that distinguish these haplotypes to the highly polymorphic BG1 locus. BG1 encodes an Ig-superfamily type I transmembrane receptor-like protein that contains an immunoreceptor tyrosine-based inhibition motif (ITIM), which undergoes phosphorylation and is recognized by Src homology 2 domain-containing protein tyrosine phosphatase (SHP-2). The recombinant haplotypes are identical, except for differences within the BG1 3′-untranslated region (3′-UTR). The 3′-UTR of the BG1 allele associated with increased lymphoma contains a 225-bp insert of retroviral origin and showed greater inhibition of luciferase reporter gene translation compared to the other allele. These findings suggest that BG1 could affect the outcome of GaHV-2 infection through modulation of the lymphoid cell responsiveness to infection, a condition that is critical for GaHV-2 replication and in which the MHC- B haplotype has been previously implicated. This work provides a mechanism by which MHC- B region genetics contributes to the incidence of GaHV-2-induced malignant lymphoma in the chicken and invites consideration of the possibility that similar mechanisms might affect the incidence of lymphomas associated with other oncogenic viral infections. |
| Databáze: | OpenAIRE |
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