Z-score mapping for standardized analysis and reporting of cardiovascular magnetic resonance modified Look-Locker inversion recovery (MOLLI) T1 data: Normal behavior and validation in patients with amyloidosis
| Autor: | Jeanette Schulz-Menger, Daniel Messroghli, Sarah Jeuthe, Matthias G. Friedrich, Titus Kuehne, Fabian aus dem Siepen, Burkert Pieske, Tiago Ferreira da Silva, Riccardo Kranzusch, Leonora Zange, Christoph Tillmanns, Stephanie Wiesemann |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
lcsh:Diseases of the circulatory (Cardiovascular) system 030204 cardiovascular system & hematology Ventricular Function Left Standard deviation 030218 nuclear medicine & medical imaging 0302 clinical medicine Germany Observer Variation Radiological and Ultrasound Technology medicine.diagnostic_test Amyloidosis Middle Aged Female Cardiomyopathies Cardiology and Cardiovascular Medicine Adult medicine.medical_specialty Inversion recovery Standard score Young Adult 03 medical and health sciences Magnetic resonance imaging Predictive Value of Tests Image Interpretation Computer-Assisted medicine Humans Radiology Nuclear Medicine and imaging In patient Aged Angiology Amyloid Neuropathies Familial Tissue analysis business.industry Research Myocardium Z-score Reproducibility of Results T1 mapping medicine.disease Myocardial disease Standardization Cardiac amyloidosis Cardiovascular and Metabolic Diseases lcsh:RC666-701 Case-Control Studies Nuclear medicine business |
| Zdroj: | Journal of Cardiovascular Magnetic Resonance, Vol 22, Iss 1, Pp 1-10 (2020) Journal of Cardiovascular Magnetic Resonance |
| Popis: | Background T1 mapping using modified Look-Locker inversion recovery (MOLLI) provides quantitative information on myocardial tissue composition. T1 results differ between sites due to variations in hardware and software equipment, limiting the comparability of results. The aim was to test if Z-scores can be used to compare the results of MOLLI T1 mapping from different cardiovascular magnetic resonance (CMR) platforms. Methods First, healthy subjects (n = 15) underwent 11 combinations of native short-axis T1 mapping (four CMR systems from two manufacturers at 1.5 T and 3 T, three MOLLI schemes). Mean and standard deviation (SD) of septal myocardial T1 were derived for each combination. T1 maps were transformed into Z-score maps based on mean and SD values using a prototype post-processing module. Second, Z-score mapping was applied to a validation sample of patients with cardiac amyloidosis at 1.5 T (n = 25) or 3 T (n = 13). Results In conventional T1 analysis, results were confounded by variations in field strength, MOLLI scheme, and manufacturer-specific system characteristics. Z-score-based analysis yielded consistent results without significant differences between any two of the combinations in part 1 of the study. In the validation sample, Z-score mapping differentiated between patients with cardiac amyloidosis and healthy subjects with the same diagnostic accuracy as standard T1 analysis regardless of field strength. Conclusions T1 analysis based on Z-score mapping provides consistent results without significant differences due to field strengths, CMR systems, or MOLLI variants, and detects cardiac amyloidosis with the same diagnostic accuracy as conventional T1 analysis. Z-score mapping provides a means to compare native T1 results acquired with MOLLI across different CMR platforms. |
| Databáze: | OpenAIRE |
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