Prolonged treadmill running in normobaric hypoxia causes gastrointestinal barrier permeability and elevates circulating levels of pro- and anti-inflammatory cytokines
| Autor: | Zach J Schall, Phebe A. Romano, Ally M. Hamilton, Garrett W. Hill, Ben J. Lee, Trevor Gillum, Matthew R. Kuennen |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Respiratory rate Physiology Endocrinology Diabetes and Metabolism Enzyme-Linked Immunosorbent Assay 030204 cardiovascular system & hematology Sensitivity and Specificity Permeability Running RC1200 Young Adult 03 medical and health sciences 0302 clinical medicine Physiology (medical) Fraction of inspired oxygen Internal medicine Heart rate medicine Humans Intestinal Mucosa Hypoxia Respiratory exchange ratio Tidal volume Nutrition and Dietetics medicine.diagnostic_test business.industry VO2 max 030229 sport sciences General Medicine QP Gastrointestinal Tract Intestines Pulse oximetry Endocrinology Gene Expression Regulation Cytokines Female business Respiratory minute volume |
| ISSN: | 1715-5312 |
| Popis: | This study examined the impact of treadmill running in normobaric hypoxia on gastrointestinal barrier permeability and the systemic inflammatory response. Ten recreationally active participants completed two 1-h bouts of matched-workload treadmill exercise (65% normoxic maximal oxygen consumption) in counterbalanced order. One bout was performed in normoxia (NORM: fraction of inspired oxygen (FIO2) = 20.9%) and the other in normobaric hypoxia (HYP: FIO2= 13.5%). Minute ventilation, respiratory rate (RR), tidal volume (VT), oxygen consumption, carbon dioxide production, respiratory exchange ratio (RER), and heart rate (HR) were measured with a metabolic cart. Peripheral oxygen saturation (SpO2) was measured with pulse oximetry. Absolute tissue saturation (StO2) was measured with near-infrared spectroscopy. Fatty acid-binding protein (I-FABP) and circulating cytokine concentrations (interleukin (IL)-1Ra, IL-6, IL-10) were assayed from plasma samples that were collected pre-exercise, postexercise, 1 h-postexercise, and 4 h-postexercise. Data were analyzed with 2-way (condition × time) repeated-measures ANOVAs. Newman–Keuls post hoc tests were run where appropriate (p < 0.05). As compared with NORM, 1 h of treadmill exercise in HYP caused greater (p < 0.05) changes in minute ventilation (+30%), RR(+16%), VT(+10%), carbon dioxide production (+18%), RER (+16%), HR (+4%), SpO2(–16%), and StO2(–10%). Gut barrier permeability and circulating cytokine concentrations were also greater (p < 0.05) following HYP exercise, where I-FABP was shown increased at postexercise (+68%) and IL-1Ra at 1 h-postexercise (+266%). I-FABP and IL-1Ra did not change (p > 0.05) following NORM exercise. IL-6 and IL-10 increased with exercise in both study conditions but were increased more (p < 0.05) following HYP at postexercise (+705% and +127%, respectively) and 1 h-postexercise (+400% and +128%, respectively).Novelty Normobaric hypoxia caused significant desaturation and increased most cardiopulmonary responses by 10%–30%. Significant gut barrier permeability and increased pro- and anti-inflammatory cytokine concentrations could promote an “open window” in the hours following HYP exercise. |
| Databáze: | OpenAIRE |
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