Pathophysiology of high fat diet induced obesity: impact of probiotic banana juice on obesity associated complications and hepatosteatosis

Autor: Vijayakumar Poondla, Reddemma Uyyala, Sreeharsha Nagaraja, Venkata Ratnam Kamsala, Lakshmi Bestha, Sridevi Tirumalaraju, Lakshman Kumar Lingamgunta, Venkata Prasad Surtineni, Sreenivasulu Dasari, Janardhan Yadav Egi, Muthukumaran Muthulingam, Anthony Johnson Antony Masilamani, Prabhakar Yellanur Konda, Bindu Prasuna Aloor, Vijayakumar Natesan, Ankanna Sade, Krishna Kumar Jaiswal, Ranjani Ramakrishnan, Sreenath Konanki
Rok vydání: 2020
Předmět:
Zdroj: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
ISSN: 2045-2322
DOI: 10.1038/s41598-020-73670-4
Popis: The high fat diet alters intestinal microbiota due to increased intestinal permeability and susceptibility to microbial antigens leads to metabolic endotoxemia. But probiotic juices reported for various health benefits. In this background we hypothesized that pectinase treated probiotic banana juice has diverse effects on HFD induced obesity and non-alcoholic steatohepatitis. 20 weeks fed HFD successfully induced obesity and its associated complications in experimental rats. The supplementation of probiotic banana juice for 5 months at a dose of 5 mL/kg bw/day resulted significant decrease (p p S. cerevisiae yeast can switch anti-obesity, antidiabetic, antioxidative stress, antioxidant and anti-hepatosteatosis effect. This study results will have significant implications for treatment of NAFLD.
Databáze: OpenAIRE