Synthesis and biological evaluation of menthol-based derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)

Autor:	Kenneth J. Shaw, Bauer Shawn M, Amy Liang, Brad O. Buckman, Wheeseong Lee, Brian D. Griedel, Ghannam Ameen F, Qingyu Wu, Zuchun Zhao, Khim Seock-Kyu, Karna Lyn Sacchi, Bin Ye
Rok vydání:	2003
Předmět:	High-throughput screening Clinical Biochemistry Drug Evaluation Preclinical Nitro compound Pharmaceutical Science Biochemistry Chemical synthesis chemistry.chemical_compound Plasminogen Activator Inhibitor 1 Drug Discovery Animals Molecular Biology chemistry.chemical_classification biology Chemistry Methanol Organic Chemistry In vitro Rats Bioavailability Enzyme inhibitor Plasminogen activator inhibitor-1 biology.protein Molecular Medicine Menthol
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 13:3361-3365
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(03)00686-3
Popis:	Compound 2 was identified by high throughput screening as a novel PAI-1 inhibitor. Systematic optimization of the A, B, and C segments of 2 resulted in the identification of a more potent compound 39 with good oral bioavailability. The synthesis and SAR data are presented in this report.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701deb338599f8ed8ca158f60220935d https://doi.org/10.1016/s0960-894x(03)00686-3 Zobrazit plný text záznamu Full Text from ScienceDirect