Chlorambucil dosage in frequently relapsingnephrotic syndrome: A controlled clinical trial
| Autor: | Linda B. Hiner, Alan B. Gruskin, H. Jorge Baluarte |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
medicine.medical_specialty
Nephrotic Syndrome Adolescent Frequently Relapsing Nephrotic Syndrome Remission Spontaneous Group ii Spontaneous remission Gastroenterology Recurrence Prednisone Internal medicine Humans Medicine Child Chlorambucil business.industry medicine.disease Surgery Clinical trial Regimen Child Preschool Pediatrics Perinatology and Child Health business Nephrotic syndrome medicine.drug |
| Zdroj: | The Journal of Pediatrics. 92:295-298 |
| ISSN: | 0022-3476 |
| DOI: | 10.1016/s0022-3476(78)80030-4 |
| Popis: | A controlled clinical trial was performed using two dosage regimens of chlorambucil to treat childrenwith frequently relapsing nephrotic syndrome. All children concurrently received prednisone (60 mg/m 2 on alternate days). Ten children (Group I) were given chlorambucil as a stable dose (0.2 mg/kg/day) for 56 to 60 days, and 11 children (Group II) received increasing doses (0.2 to 0.63 mg/kg/day) for 42 to 77 days. Two children in each group subsequently relapsed. Follow-up averaged 28.6 and 27.2 months in Groups I and II, respectively. Three children in Group II developed infectious complications. The data indicate that a stable dosage regimen for chlorambucil is as effective as an increasing dose regimen in achieving long-term remission of frequently relapsing nephrotic syndrome. |
| Databáze: | OpenAIRE |
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