Age changes of human serum polyreactive immunoglobulins (PRIG) activity
| Autor: | Demchenko Ma, Komisarenko Sv, Bobrovnik Sa |
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| Rok vydání: | 2015 |
| Předmět: |
Functional role
Immunoglobulin A Adult Male Aging Serum albumin Plasma protein binding Biochemistry Immunoglobulin G lcsh:Biochemistry Antigen-Antibody Reactions Antibody Specificity Humans lcsh:QD415-436 Serum Albumin Aged age changes Age changes biology Chemistry Age Factors Immunoglobulin M Immunology biology.protein activity of polyreactive IgG ELISA Female Antibody Protein Binding |
| Zdroj: | Ukrainian Biochemical Journal, Vol 86, Iss 5, Pp 151-155 (2014) |
| ISSN: | 2409-4943 |
| Popis: | It has been determined that activity of serum polyreactive immunoglobulins (PRIG) changes with age in practically healthy people at the age from twenty five to seventy. Therewith, the activity of serum IgG PRIG increases most of all (about 3-4 times), while IgM PRIG activity, on the contrary, does not increase, but sometimes even decreases with age. IgA PRIG activity varies significantly more than IgG PRIG activity and, besides, IgА PRIG significantly less depends on age than IgG PRIG. The age changes in the activity of human serum PRIG, belonging to different types of immunoglobulins, may evidence for the important functional role of these immunoglobulins that has to be clarified. |
| Databáze: | OpenAIRE |
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