Discovery of 3,5-disubstituted-1H-pyrrolo[2,3-b]pyridines as potent inhibitors of the insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase

Autor:	Huangshu Lei, Anne M. Hassell, Rakesh Kumar, M. Anthony Leesnitzer, Toshihiro Hamajima, Felix Deanda, Hiroko Nakamura, Stanley D. Chamberlain, J. Brad Shotwell, Jun Tang, Roseanne Gerding, Samarjit Patnaik, Lisa M. Shewchuck, Kirk L. Stevens
Rok vydání:	2008
Předmět:	Pyridines medicine.medical_treatment Clinical Biochemistry Pharmaceutical Science Biochemistry Receptor IGF Type 1 Insulin-like growth factor Structure-Activity Relationship Growth factor receptor Drug Discovery medicine Pyrroles Tyrosine Molecular Biology Protein Kinase Inhibitors Insulin-like growth factor 1 receptor chemistry.chemical_classification biology Chemistry Organic Chemistry Enzyme Enzyme inhibitor Drug Design biology.protein Molecular Medicine Signal transduction Tyrosine kinase
Zdroj:	Bioorganicmedicinal chemistry letters. 19(11)
ISSN:	1464-3405
Popis:	Exploration of the SAR around a series of 3,5-disubstituted-1H-pyrrolo[2,3-b]pyridines led to the discovery of novel pyrrolopyridine inhibitors of the IGF-1R tyrosine kinase. Several compounds demonstrated nanomolar potency in enzyme and cellular mechanistic assays.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701863fa69f3d183d14561c2ba78ff87 https://pubmed.ncbi.nlm.nih.gov/19394223 Zobrazit plný text záznamu Full Text from ScienceDirect